NP_002745
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44.2 kDa (385aa), confirmed by MALDI-TOF
NCBI Official Full Name
mitogen-activated protein kinase 13
NCBI Official Synonym Full Names
mitogen-activated protein kinase 13
NCBI Official Synonym Symbols
SAPK4; PRKM13; MAPK 13; MAPK-13; p38delta [Similar Products]
NCBI Protein Information
mitogen-activated protein kinase 13
UniProt Protein Name
Mitogen-activated protein kinase 13
UniProt Synonym Protein Names
Mitogen-activated protein kinase p38 delta; MAP kinase p38 delta; Stress-activated protein kinase 4
UniProt Synonym Gene Names
NCBI Summary for MAPK13
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for MAPK13
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
Product References and Citations for MAPK13 recombinant protein
Nishida E. et al. (1993) Trends Biochem. Sci. 18: 128-131.; Wang X.S. et al. (1997) J. Biol. Chem. 272: 23668-23674.
Research Articles on MAPK13
Precautions
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Products associated with MAPK13 recombinant protein
Pathways associated with MAPK13 recombinant protein
Diseases associated with MAPK13 recombinant protein
Organs/Tissues associated with MAPK13 recombinant protein
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