View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List MEC active protein Catalog # MBS539440 Unit / Price 0.02 mg / $475 +1 FREE 8GB USB 5x0.02 mg / $1,955 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name MEC, Active Protein Full Product Name MEC protein Product Synonym Names CCL28 protein; Mucosae-associated Epithelial Chemokine protein; CCK-1 protein Product Gene Name MEC active protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence Region of MEC protein correspond ing to amino acids SEAILPIASS CCTEVSHHIS RRLLERVNMC RIQRADGDCD LAAVILHVKR RRICVSPHNH TVKQWMKVQA AKKNGKGNVC HRKKHHGKRN SNRAHQGKHE TYGHKTPY. OMIM 605240 3D Structure ModBase 3D Structure for Q9NRJ3 Host Human Purity/Purification > 98% pure Form/Format Supplied as a lyophilized powder. Protein Type Recombinant Biological Significance MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Bioactivity Determined by its ability to chemoattract human lymphoytes using a concentration range of 1.0-10.0 ng/ml. Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Expression System E Coli Preparation and Storage Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles. Active Protein Note Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product. Other Notes Small volumes of MEC active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for MEC active protein Purified recombinant Human MEC protein Product Categories/Family for MEC active protein Cytokines & Growth Factors Applications Tested/Suitable for MEC active protein User optimized TOP NCBI/Uniprot data below describe general gene information for MEC. It may not necessarily be applicable to this product. NCBI GI # 10312152 NCBI GeneID 56477 NCBI Accession # AAG16691.1 [Other Products] UniProt Primary Accession # Q9NRJ3 [Other Products] UniProt Secondary Accession # D7RIE7[Other Products] UniProt Related Accession # Q9NRJ3[Other Products] Molecular Weight 12.3 kDa TOP NCBI Official Full Name mucosae-associated epithelial chemokine NCBI Official Synonym Full Names chemokine (C-C motif) ligand 28 NCBI Official Symbol CCL28 [Similar Products] NCBI Official Synonym Symbols MEC; CCK1; SCYA28 [Similar Products] NCBI Protein Information C-C motif chemokine 28 UniProt Protein Name C-C motif chemokine 28 UniProt Synonym Protein Names Mucosae-associated epithelial chemokine; MEC; Protein CCK1; Small-inducible cytokine A28 Protein Family Meckelin UniProt Gene Name CCL28 [Similar Products] UniProt Synonym Gene Names SCYA28; MEC [Similar Products] UniProt Entry Name CCL28_HUMAN TOP NCBI Summary for MEC This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] TOP UniProt Comments for MEC CCL28: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. Belongs to the intercrine beta (chemokine CC) family.Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; ChemokineChromosomal Location of Human Ortholog: 5p12Cellular Component: extracellular space; extracellular regionMolecular Function: chemokine activityBiological Process: elevation of cytosolic calcium ion concentration; immune response; chemotaxis; positive regulation of cell-matrix adhesion; response to nutrient Research Articles on MEC 1. CCL28 is a potent growth-promoting factor with the ability to support the in vitro and in vivo functional properties of cultured human hematopoietic cells. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with MEC active protein Reference Product PubMed Publications CCR10 active protein >51 publications with MEC and CCR10 CCL25 active protein >32 publications with MEC and CCL25 CCK active protein >22 publications with MEC and CCK CXCL12 active protein >19 publications with MEC and CXCL12 CCR9 active protein >19 publications with MEC and CCR9 CCR3 active protein >17 publications with MEC and CCR3 CCL21 active protein >14 publications with MEC and CCL21 CCL20 active protein >11 publications with MEC and CCL20 PYY active protein >2 publications with MEC and PYY CXCR5 active protein >2 publications with MEC and CXCR5 Pathways associated with MEC active protein Products by Pathway Pathway Diagram Chemokine Receptors Bind Chemokines Pathway antibodies Chemokine Receptors Bind Chemokines Pathway Diagram Chemokine Signaling Pathway antibodies Chemokine Signaling Pathway Diagram Chemokine Signaling Pathway antibodies Chemokine Signaling Pathway Diagram Class A/1 (Rhodopsin-like Receptors) Pathway antibodies Class A/1 (Rhodopsin-like Receptors) Pathway Diagram Cytokine-cytokine Receptor Interaction Pathway antibodies Cytokine-cytokine Receptor Interaction Pathway Diagram Cytokine-cytokine Receptor Interaction Pathway antibodies Cytokine-cytokine Receptor Interaction Pathway Diagram G Alpha (i) Signalling Events Pathway antibodies G Alpha (i) Signalling Events Pathway Diagram GPCR Downstream Signaling Pathway antibodies GPCR Downstream Signaling Pathway Diagram GPCR Ligand Binding Pathway antibodies GPCR Ligand Binding Pathway Diagram Intestinal Immune Network For IgA Production Pathway antibodies Intestinal Immune Network For IgA Production Pathway Diagram Diseases associated with MEC active protein Disease Name Pubmed Publications Inflammation Antibodies >29 publications with MEC and Inflammation Necrosis Antibodies >12 publications with MEC and Necrosis Liver Diseases Antibodies >7 publications with MEC and Liver Diseases Carcinoma Antibodies >7 publications with MEC and Carcinoma Adenocarcinoma Antibodies >7 publications with MEC and Adenocarcinoma Respiratory Tract Infections Antibodies >3 publications with MEC and Respiratory Tract Infections Male Urogenital Diseases Antibodies >3 publications with MEC and Male Urogenital Diseases Genital Diseases, Female Antibodies >2 publications with MEC and Genital Diseases, Female Kidney Diseases Antibodies >2 publications with MEC and Kidney Diseases Cell Transformation, Neoplastic Antibodies >2 publications with MEC and Cell Transformation, Neoplastic Organs/Tissues associated with MEC active protein Organ/Tissue Name Pubmed Publications Liver Antibodies >13 publications with MEC and Liver Brain Antibodies >12 publications with MEC and Brain Mammary Gland Antibodies >11 publications with MEC and Mammary Gland Thymus Antibodies >9 publications with MEC and Thymus Stomach Antibodies >7 publications with MEC and Stomach Muscle Antibodies >5 publications with MEC and Muscle Bone Marrow Antibodies >5 publications with MEC and Bone Marrow Trachea Antibodies >4 publications with MEC and Trachea Pharynx Antibodies >4 publications with MEC and Pharynx Placenta Antibodies >1 publications with MEC and Placenta TOP © 2006-24 MyBioSource.com. 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