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Add To Compare List Mapt recombinant protein :: Microtubule-associated protein tau (Mapt) Recombinant Protein Catalog # MBS964528 Unit / Price 0.02 mg (E-Coli) / $1,315 +1 FREE 8GB USB 0.1 mg (E-Coli) / $1,590 +1 FREE 8GB USB 0.02 mg (Baculovirus) / $1,590 +1 FREE 8GB USB 0.1 mg (Baculovirus) / $2,230 +2 FREE 8GB USB 1 mg (E-Coli) / $2,845 +3 FREE 8GB USB 1 mg (Baculovirus) / $4,380 +5 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Microtubule-associated protein tau (Mapt), Recombinant Protein Popular Item Full Product Name Recombinant Mouse Microtubule-associated protein tau (Mapt) Product Gene Name Mapt recombinant protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP MBS964528 COA COA PDF Sequence Positions 2-733aa; Full Length of Mature Protein Sequence ADPRQEFDTM EDHAGDYTLL QDQEGDMDHG LKESPPQPPA DDGAEEPGSE TSDAKSTPTA EDVTAPLVDE RAPDKQAAAQ PHTEIPEGIT AEEAGIGDTP NQEDQAAGHV TQGRREGQAP DLGTSDWTRQ QVSSMSGAPL LPQGLREATC QPSGTRPEDI EKSHPASELL RRGPPQKEGW GQDRLGSEEE VDEDLTVDES SQDSPPSQAS LTPGRAAPQA GSGSVCGETA SVPGLPTEGS VPLPADFFSK VSAETQASQP EGPGTGPMEE GHEAAPEFTF HVEIKASTPK EQDLEGATVV GVPGEEQKAQ TQGPSVGKGT KEASLQEPPG KQPAAGLPGR PVSRVPQLKA RVASKDRTGN DEKKAKTSTP SCAKAPSHRP CLSPTRPTLG SSDPLIKPSS PAVSPEPATS PKHVSSVTPR NGSPGTKQMK LKGADGKTGA KIATPRGAAS PAQKGTSNAT RIPAKTTPSP KTPPGSGEPP KSGERSGYSS PGSPGTPGSR SRTPSLPTPP TREPKKVAVV RTPPKSPSAS KSRLQTAPVP MPDLKNVRSK IGSTENLKHQ PGGGKVQIIN KKLDLSNVQS KCGSKDNIKH VPGGGSVQIV YKPVDLSKVT SKCGSLGNIH HKPGGGQVEV KSEKLDFKDR VQSKIGSLDN ITHVPGGGNK KIETHKLTFR ENAKAKTDHG AEIVYKSPVV SGDTSPRHLS NVSSTGSIDM VDSPQLATLA DEVSASLAKQ GL 3D Structure ModBase 3D Structure for P10637 Host E Coli or Yeast or Baculovirus or Mammalian Cell Purity/Purification Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific) Form/Format Lyophilized or liquid (Format to be determined during the manufacturing process) Tag Information This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information. Sterility Sterile filter available upon request. Endotoxin Low endotoxin available upon request. Species Mouse Production Note Special Offer: The Yeast host-expressed protein is manufactured from a stock plasmid containing the protein gene. Yeasthost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Yeast host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Yeast host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to [email protected] for more details. Preparation and Storage Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of Mapt recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for Mapt recombinant protein This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer s disease, Pick s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. SDS-Page of Mapt recombinant protein (Note: Representative image, actual molecular weight may vary depending on Tag type and expression host) TOP NCBI/Uniprot data below describe general gene information for Mapt. It may not necessarily be applicable to this product. NCBI GI # 84370347 NCBI GeneID 17762 NCBI Accession # NP_001033698.1 [Other Products] NCBI GenBank Nucleotide # NM_001038609.2 [Other Products] UniProt Primary Accession # P10637 [Other Products] UniProt Secondary Accession # P10638; Q60684; Q60685; Q60686; Q62286; Q91WK4; A2A5Y9[Other Products] UniProt Related Accession # P10637[Other Products] Molecular Weight 78.1 kDa TOP NCBI Official Full Name microtubule-associated protein tau isoform a NCBI Official Synonym Full Names microtubule-associated protein tau NCBI Official Symbol Mapt [Similar Products] NCBI Official Synonym Symbols Tau; Mtapt; AI413597; AW045860 [Similar Products] NCBI Protein Information microtubule-associated protein tau UniProt Protein Name Microtubule-associated protein tau UniProt Synonym Protein Names Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau Protein Family Microtubule-associated protein UniProt Gene Name Mapt [Similar Products] UniProt Synonym Gene Names Mtapt; Tau; PHF-tau [Similar Products] TOP TOP UniProt Comments for Mapt Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Research Articles on Mapt 1. results demonstrate that ApoE affects tau pathogenesis, neuroinflammation, and tau-mediated neurodegeneration independently of amyloid-beta pathology; ApoE4 exerts a 'toxic' gain of function whereas the absence of ApoE is protective TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with Mapt recombinant protein Reference Product PubMed Publications Gsk3b recombinant protein >73 publications with Mapt and Gsk3b Cdk5 recombinant protein >40 publications with Mapt and Cdk5 Casp3 recombinant protein >37 publications with Mapt and Casp3 Fyn recombinant protein >10 publications with Mapt and Fyn Cdk5r1 recombinant protein >4 publications with Mapt and Cdk5r1 Bin1 recombinant protein >3 publications with Mapt and Bin1 Mark2 recombinant protein >2 publications with Mapt and Mark2 Mark1 recombinant protein >1 publications with Mapt and Mark1 Hspa8 recombinant protein >1 publications with Mapt and Hspa8 Pathways associated with Mapt recombinant protein Products by Pathway Pathway Diagram Alzheimer's Disease Pathway antibodies Alzheimer's Disease Pathway Diagram Alzheimer's Disease Pathway antibodies Alzheimer's Disease Pathway Diagram Alzheimers Disease Pathway antibodies Alzheimers Disease Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptotic Cleavage Of Cellular Proteins Pathway antibodies Apoptotic Cleavage Of Cellular Proteins Pathway Diagram Apoptotic Execution Phase Pathway antibodies Apoptotic Execution Phase Pathway Diagram Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram IL-6 Signaling Pathway antibodies IL-6 Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram Diseases associated with Mapt recombinant protein Disease Name Pubmed Publications Nervous System Diseases Antibodies >1527 publications with Mapt and Nervous System Diseases Neurodegenerative Diseases Antibodies >1412 publications with Mapt and Neurodegenerative Diseases Brain Diseases Antibodies >1389 publications with Mapt and Brain Diseases Dementia Antibodies >1275 publications with Mapt and Dementia Tauopathies Antibodies >1052 publications with Mapt and Tauopathies Alzheimer Disease Antibodies >852 publications with Mapt and Alzheimer Disease Frontotemporal Dementia Antibodies >487 publications with Mapt and Frontotemporal Dementia Movement Disorders Antibodies >342 publications with Mapt and Movement Disorders Disease Models, Animal Antibodies >257 publications with Mapt and Disease Models, Animal Parkinsonian Disorders Antibodies >253 publications with Mapt and Parkinsonian Disorders Organs/Tissues associated with Mapt recombinant protein Organ/Tissue Name Pubmed Publications Brain Antibodies >1133 publications with Mapt and Brain Blood Antibodies >137 publications with Mapt and Blood Spinal Cord Antibodies >46 publications with Mapt and Spinal Cord Muscle Antibodies >30 publications with Mapt and Muscle Eye Antibodies >27 publications with Mapt and Eye Heart Antibodies >19 publications with Mapt and Heart Embryonic Tissue Antibodies >13 publications with Mapt and Embryonic Tissue Liver Antibodies >11 publications with Mapt and Liver Kidney Antibodies >7 publications with Mapt and Kidney Skin Antibodies >7 publications with Mapt and Skin TOP © 2006-24 MyBioSource.com. 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