Product References and Citations for
NFKB1 recombinant protein
The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product.Kieran M., Blank V., Logeat F., Vandekerckhove J., Lottspeich F., le Bail O., Urban M.B., Kourilsky P., Baeuerle P.A., Israel A.Cell 62:1007-1018(1990)
Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs.Bours V., Villalobos J., Burd P.R., Kelly K., Siebenlist U.Nature 348:76-80(1990)
Cloning of the DNA-binding subunit of human nuclear factor kappa B
the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha.Meyer R., Hatada E.N., Hohmann H.-P., Haiker M., Bartsch C., Roethlisberger U., Lahm H.-W., Schlaeger E.J., van Loon A.P.G.M., Scheidereit C.Proc. Natl. Acad. Sci. U.S.A. 88:966-970(1991)
The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappa B and I kappa B-gamma
implications for NF-kappa B-mediated signal transduction.Heron E., Deloukas P., van Loon A.P.G.M.Genomics 30:493-505(1995)
Genome sequencing of the chromosome 4q region implicated in human hepatocellular carcinoma pathogenesis.Chang H.-M., Tsai S.-F.Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004)
The full-ORF clone resource of the German cDNA consortium.Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.BMC Genomics 8:399-399(2007)
NIEHS SNPs program
A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.Hansen S.K., Nerlov C., Zabel U., Verde P., Johnsen M., Baeuerle P.A., Blasi F.EMBO J. 11:205-213(1992)
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B.Palombella V.J., Rando O.J., Goldberg A.L., Maniatis T.Cell 78:773-785(1994)
Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.Beg A.A., Baldwin A.S. Jr.Oncogene 9:1487-1492(1994)
A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit.Lin L., Ghosh S.Mol. Cell. Biol. 16:2248-2254(1996)
Inhibition of NF-kappaB DNA binding by nitric oxide.Matthews J.R., Botting C.H., Panico M., Morris H.R., Hay R.T.Nucleic Acids Res. 24:2236-2242(1996)
A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)
-mediated NF-kappaB transcription.Li Z., Nabel G.J.Mol. Cell. Biol. 17:6184-6190(1997)
Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome.Lin L., De;Martino G.N., Greene W.C.Cell 92:819-828(1998)
NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.Heissmeyer V., Krappmann D., Wulczyn F.G., Scheidereit C.EMBO J. 18:4766-4778(1999)
TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105.Belich M.P., Salmeron A., Johnston L.H., Ley S.C.Nature 397:363-368(1999)
Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production.Lin L., De;Martino G.N., Greene W.C.EMBO J. 19:4712-4722(2000)
RAC-3 is a NF-kappa B coactivator.Werbajh S., Nojek I., Lanz R., Costas M.A.FEBS Lett. 485:195-199(2000)
Inhibition of NF-kappaB by S-nitrosylation.Marshall H.E., Stamler J.S.Biochemistry 40:1688-1693(2001)
Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B.Ayroldi E., Migliorati G., Bruscoli S., Marchetti C., Zollo O., Cannarile L., D'Adamio F., Riccardi C.Blood 98:743-753(2001)
15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit.Cernuda-Morollon E., Pineda-Molina E., Canada F.J., Perez-Sala D.J. Biol. Chem. 276:35530-35536(2001)
Direct phosphorylation of NF-kappa B1 p105 by the Ikappa B kinase complex on serine 927 is essential for signal-induced p105 proteolysis.Salmeron A., Janzen J., Soneji Y., Bump N., Kamens J., Allen H., Ley S.C.J. Biol. Chem. 276:22215-22222(2001)
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.Heppner C., Bilimoria K.Y., Agarwal S.K., Kester M., Whitty L.J., Guru S.C., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Marx S.J., Burns A.L.Oncogene 20:4917-4925(2001)
Casper/c-FLIP is physically and functionally associated with NF-kappaB1 p105.Li Z., Zhang J., Chen D., Shu H.B.Biochem. Biophys. Res. Commun. 309:980-985(2003)
Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins.Furia B., Deng L., Wu K., Baylor S., Kehn K., Li H., Donnelly R., Coleman T., Kashanchi F.J. Biol. Chem. 277:4973-4980(2002)
Synthesis of glucocorticoid-induced leucine zipper (GILZ)
by macrophages
an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10.Berrebi D., Bruscoli S., Cohen N., Foussat A., Migliorati G., Bouchet-Delbos L., Maillot M.-C., Portier A., Couderc J., Galanaud P., Peuchmaur M., Riccardi C., Emilie D.Blood 101:729-738(2003)
Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation.Deng W.G., Zhu Y., Wu K.K.J. Biol. Chem. 278:4770-4777(2003)
Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability.Demarchi F., Bertoli C., Sandy P., Schneider C.J. Biol. Chem. 278:39583-39590(2003)
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.Lang V., Janzen J., Fischer G.Z., Soneji Y., Beinke S., Salmeron A., Allen H., Hay R.T., Ben-Neriah Y., Ley S.C.Mol. Cell. Biol. 23:402-413(2003)
Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.Zhang J., Xu L.-G., Han K.-J., Shu H.-B.J. Biol. Chem. 279:17819-17825(2004)
ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.Lang V., Symons A., Watton S.J., Janzen J., Soneji Y., Beinke S., Howell S., Ley S.C.Mol. Cell. Biol. 24:5235-5248(2004)
Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription factor in human macrophages
involvement in cytokine synthesis.Guizani-Tabbane L., Ben-Aissa K., Belghith M., Sassi A., Dellagi K.Infect. Immun. 72:2582-2589(2004)
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.Beinke S., Robinson M.J., Hugunin M., Ley S.C.Mol. Cell. Biol. 24:9658-9667(2004)
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.Bouwmeester T., Bauch A., Ruffner H., Angrand P.-O., Bergamini G., Croughton K., Cruciat C., Eberhard D., Gagneur J., Ghidelli S., Hopf C., Huhse B., Mangano R., Michon A.-M., Schirle M., Schlegl J., Schwab M., Stein M.A., Bauer A., Casari G., Drewes G., Gavin A.-C., Jackson D.B., Joberty G., Neubauer G., Rick J., Kuster B., Superti-Furga G.Nat. Cell Biol. 6:97-105(2004)
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF)
asparaginyl hydroxylase, factor inhibiting HIF (FIH)
.Cockman M.E., Lancaster D.E., Stolze I.P., Hewitson K.S., McDonough M.A., Coleman M.L., Coles C.H., Yu X., Hay R.T., Ley S.C., Pugh C.W., Oldham N.J., Masson N., Schofield C.J., Ratcliffe P.J.Proc. Natl. Acad. Sci. U.S.A. 103:14767-14772(2006)
A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.Sci. Signal. 2:RA46-RA46(2009)
Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011)
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014)
Structure of the NF-kappa B p50 homodimer bound to DNA.Mueller C.W., Rey F.A., Sodeoka M., Verdine G.L., Harrison S.C.Nature 373:311-317(1995)
Structure of an IkappaBalpha/NF-kappaB complex.Jacobs M.D., Harrison S.C.Cell 95:749-758(1998)
Solution structure of the death domain in human nuclear factor NF-kappa-B p105 subunit.RIKEN structural genomics initiative (RSGI)
Submitted (DEC-2006)
to the PDB data bank+Additional computationally mapped references.<p>Provides general information on the entry.