NP_075601
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29.4kDa (254aa) confirmed by MALDI-TOF
NCBI Official Full Name
ubiquitin thioesterase OTUB2
NCBI Official Synonym Full Names
OTU deubiquitinase, ubiquitin aldehyde binding 2
NCBI Protein Information
ubiquitin thioesterase OTUB2
UniProt Protein Name
Ubiquitin thioesterase OTUB2
UniProt Synonym Protein Names
Deubiquitinating enzyme OTUB2; OTU domain-containing ubiquitin aldehyde-binding protein 2; Otubain-2; Ubiquitin-specific-processing protease OTUB2
UniProt Synonym Gene Names
NCBI Summary for OTuB2
This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]
UniProt Comments for OTuB2
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.
Product References and Citations for OTuB2 recombinant protein
Balakirev MY, et al. (2003) EMBO Rep 4 (5): 517-22.; Edelmann M.J., et al. (2009) Biochem. J. 418:379-390
Research Articles on OTuB2
Precautions
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Disclaimer
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Products associated with OTuB2 recombinant protein
Pathways associated with OTuB2 recombinant protein
Diseases associated with OTuB2 recombinant protein
Organs/Tissues associated with OTuB2 recombinant protein
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