NP_006187
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19.6 kDa (186aa) confirmed by MALDI-TOF
NCBI Official Full Name
poly(rC)-binding protein 1
NCBI Official Synonym Full Names
poly(rC) binding protein 1
NCBI Official Synonym Symbols
HNRPX; HNRPE1; hnRNP-X; HEL-S-85; hnRNP-E1 [Similar Products]
NCBI Protein Information
poly(rC)-binding protein 1
UniProt Protein Name
Poly(rC)-binding protein 1
UniProt Synonym Protein Names
Alpha-CP1; Heterogeneous nuclear ribonucleoprotein E1; hnRNP E1; Nucleic acid-binding protein SUB2.3
UniProt Synonym Gene Names
NCBI Summary for PCBP1
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
UniProt Comments for PCBP1
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).
Product References and Citations for PCBP1 recombinant protein
Beausoleil S.A., et al. (2006) Nat. Biotechnol. 24:1285-1292; Yu L.-R., et al. (2007) J. Proteome Res. 6:4150-4162;
Research Articles on PCBP1
Precautions
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Products associated with PCBP1 recombinant protein
Pathways associated with PCBP1 recombinant protein
Diseases associated with PCBP1 recombinant protein
Organs/Tissues associated with PCBP1 recombinant protein
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