AAF37293
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
84 kDa (750 aa)
NCBI Official Full Name
protein arginine N-methyltransferase 1
NCBI Official Synonym Full Names
protein arginine N-methyltransferase 1
NCBI Official Synonym Symbols
Mrmt1; Hrmt1l2; AW214366; 6720434D09Rik [Similar Products]
NCBI Protein Information
protein arginine N-methyltransferase 1
UniProt Protein Name
Protein arginine N-methyltransferase 1
UniProt Synonym Protein Names
Histone-arginine N-methyltransferase PRMT1
UniProt Synonym Gene Names
UniProt Comments for PRMT1
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity. Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (). Promotes colorectal cancer cell malignancy ().
Product References and Citations for PRMT1 active protein
Herrmann F., et al. (2005). J Biol Chem. 280 (45):38005-10.; Abramovich C., et al. (1997). EMBO J. 16 (2):260-6. ;
Research Articles on PRMT1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with PRMT1 active protein
Pathways associated with PRMT1 active protein
Diseases associated with PRMT1 active protein
Organs/Tissues associated with PRMT1 active protein
|