NP_000945.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34.7 kDa
NCBI Official Full Name
prostaglandin-H2 D-isomerase
NCBI Official Synonym Full Names
prostaglandin D2 synthase
NCBI Official Synonym Symbols
PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS [Similar Products]
NCBI Protein Information
prostaglandin-H2 D-isomerase
UniProt Protein Name
Prostaglandin-H2 D-isomerase
UniProt Synonym Protein Names
Beta-trace protein; Cerebrin-28; Glutathione-independent PGD synthase; Lipocalin-type prostaglandin-D synthase; Prostaglandin-D2 synthase; PGD2 synthase; PGDS; PGDS2
UniProt Synonym Gene Names
UniProt Entry Name
PTGDS_HUMAN
NCBI Summary for PTGDS
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
UniProt Comments for PTGDS
PTGDS: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Belongs to the calycin superfamily. Lipocalin family.
Protein type: Isomerase; EC 5.3.99.2; Endoplasmic reticulum; Secreted, signal peptide; Lipid Metabolism - arachidonic acid; Secreted
Chromosomal Location of Human Ortholog: 9q34.2-q34.3
Cellular Component: endoplasmic reticulum membrane; extracellular region; extracellular space; Golgi apparatus; nuclear membrane; perinuclear region of cytoplasm; rough endoplasmic reticulum
Molecular Function: fatty acid binding; prostaglandin-D synthase activity; protein binding; retinoid binding; transporter activity
Biological Process: arachidonic acid metabolic process; cyclooxygenase pathway; prostaglandin biosynthetic process; regulation of circadian sleep/wake cycle, sleep; response to glucocorticoid stimulus; transport
Product References and Citations for PTGDS recombinant protein
Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins.Nagata A., Suzuki Y., Igarashi M., Eguchi N., Toh H., Urade Y., Hayaishi O.Proc. Natl. Acad. Sci. U.S.A. 88:4020-4024(1991)
Research Articles on PTGDS
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Pathways associated with PTGDS recombinant protein
Diseases associated with PTGDS recombinant protein
Organs/Tissues associated with PTGDS recombinant protein
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