NP_002863.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,429 Da
NCBI Official Full Name
ras-related C3 botulinum toxin substrate 2
NCBI Official Synonym Full Names
Rac family small GTPase 2
NCBI Protein Information
ras-related C3 botulinum toxin substrate 2
UniProt Protein Name
Ras-related C3 botulinum toxin substrate 2
UniProt Synonym Protein Names
GX; Small G protein; p21-Rac2
NCBI Summary for RAC2
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]
UniProt Comments for RAC2
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Research Articles on RAC2
Precautions
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Disclaimer
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Products associated with RAC2 recombinant protein
Pathways associated with RAC2 recombinant protein
Diseases associated with RAC2 recombinant protein
Organs/Tissues associated with RAC2 recombinant protein
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