NP_005861.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,561 Da
NCBI Official Full Name
histone deacetylase complex subunit SAP18
NCBI Official Synonym Full Names
Sin3A-associated protein, 18kDa
NCBI Protein Information
histone deacetylase complex subunit SAP18; 18 kDa Sin3-associated polypeptide; cell growth inhibiting protein 38; cell growth-inhibiting gene 38 protein; cell growth-inhibiting protein 38; histone deacetlyase complex subunit SAP18; sin3-associated polypeptide p18; sin3-associated polypeptide, 18 kDa; sin3-associated polypeptide, p18
UniProt Protein Name
Histone deacetylase complex subunit SAP18
UniProt Synonym Protein Names
18 kDa Sin3-associated polypeptide; 2HOR0202; Cell growth-inhibiting gene 38 protein; Sin3-associated polypeptide p18
UniProt Entry Name
SAP18_HUMAN
NCBI Summary for SAP18
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
UniProt Comments for SAP18
SAP18: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Belongs to the SAP18 family.
Chromosomal Location of Human Ortholog: 13q12.11
Cellular Component: nucleoplasm; cytoplasm; histone deacetylase complex; nuclear speck
Molecular Function: protein binding; transcription corepressor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; negative regulation of nuclear mRNA splicing, via spliceosome; negative regulation of gene expression, epigenetic; positive regulation of apoptosis; RNA splicing; gene expression; mRNA processing; regulation of gene expression, epigenetic; regulation of alternative nuclear mRNA splicing, via spliceosome
Research Articles on SAP18
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Products associated with SAP18 recombinant protein
Pathways associated with SAP18 recombinant protein
Organs/Tissues associated with SAP18 recombinant protein
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