NP_001274671.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52.0 kDa
NCBI Official Full Name
squalene synthase isoform 1
NCBI Official Synonym Full Names
farnesyl-diphosphate farnesyltransferase 1
NCBI Protein Information
squalene synthase
UniProt Protein Name
Squalene synthase
UniProt Synonym Protein Names
FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase
UniProt Synonym Gene Names
UniProt Entry Name
FDFT_HUMAN
NCBI Summary for FDFT1
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
UniProt Comments for FDFT1
FDFT1: a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
Protein type: EC 2.5.1.21; Membrane protein, integral; Membrane protein, multi-pass; Transferase; Lipid Metabolism - steroid biosynthesis; Oxidoreductase; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 8p23.1-p22
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane
Molecular Function: farnesyl-diphosphate farnesyltransferase activity; oxidoreductase activity
Biological Process: cellular lipid metabolic process; cholesterol biosynthetic process; farnesyl diphosphate metabolic process; isoprenoid biosynthetic process; steroid biosynthetic process
Product References and Citations for FDFT1 recombinant protein
"Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems."
Soltis D.A., McMahon G., Caplan S.L., Dudas D.A., Chamberlin H.A., Vattay A., Dottavio D., Rucker M.L., Engstrom R.G., Cornell-Kennon S.A.
Arch. Biochem. Biophys. 316:713-723(1995)
Research Articles on FDFT1
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Products associated with FDFT1 recombinant protein
Pathways associated with FDFT1 recombinant protein
Diseases associated with FDFT1 recombinant protein
Organs/Tissues associated with FDFT1 recombinant protein
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