NP_001277342.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,757 Da
NCBI Official Full Name
TNF receptor-associated factor 2 isoform a
NCBI Official Synonym Full Names
TNF receptor-associated factor 2
NCBI Official Synonym Symbols
NCBI Protein Information
TNF receptor-associated factor 2
UniProt Protein Name
TNF receptor-associated factor 2
UniProt Synonym Protein Names
E3 ubiquitin-protein ligase TRAF2; RING-type E3 ubiquitin transferase TRAF2Curated
UniProt Comments for Traf2
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
Research Articles on Traf2
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Products associated with Traf2 recombinant protein
Pathways associated with Traf2 recombinant protein
Diseases associated with Traf2 recombinant protein
Organs/Tissues associated with Traf2 recombinant protein
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