NP_115729
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23.3 kDa (200aa), confirmed by MALDI-TOF
NCBI Official Full Name
vacuolar protein-sorting-associated protein 25
NCBI Official Synonym Full Names
vacuolar protein sorting 25 homolog
NCBI Protein Information
vacuolar protein-sorting-associated protein 25
UniProt Protein Name
Vacuolar protein-sorting-associated protein 25
UniProt Synonym Protein Names
Dermal papilla-derived protein 9; ELL-associated protein of 20 kDa; ESCRT-II complex subunit VPS25
UniProt Synonym Gene Names
NCBI Summary for VPS25
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013]
UniProt Comments for VPS25
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.
Product References and Citations for VPS25 recombinant protein
Bailey,S.D. et al. (2010) Diabetes Care 33 (10), 2250-2253; Talmud,P.J. et al. (2009) Am. J. Hum. Genet. 85 (5), 628-642;
Research Articles on VPS25
Precautions
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Disclaimer
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Products associated with VPS25 recombinant protein
Pathways associated with VPS25 recombinant protein
Diseases associated with VPS25 recombinant protein
Organs/Tissues associated with VPS25 recombinant protein
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