NP_001099439.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
vang-like protein 2
NCBI Official Synonym Full Names
vang-like 2 (van gogh, Drosophila)
NCBI Official Synonym Symbols
NCBI Protein Information
vang-like protein 2; van Gogh-like protein 2; loop tail associated protein
UniProt Protein Name
Vang-like protein 2
UniProt Synonym Protein Names
Van Gogh-like protein 2
UniProt Entry Name
VANG2_RAT
UniProt Comments for Vangl2
VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Adaptor/scaffold
Cellular Component: basolateral plasma membrane; apical plasma membrane; plasma membrane; stress fiber; integral to membrane; intercellular junction; intracellular; ER to Golgi transport vesicle; lateral plasma membrane
Biological Process: positive regulation of JNK activity; convergent extension involved in axis elongation; wound healing; Wnt receptor signaling pathway, planar cell polarity pathway; somatic stem cell maintenance; inner ear receptor cell development; convergent extension involved in neural plate elongation; regulation of Wnt receptor signaling pathway; digestive tract morphogenesis; glomerulus development; Rho protein signal transduction; anterior/posterior pattern formation; establishment and/or maintenance of epithelial cell polarity; convergent extension involved in organogenesis; apical protein localization; inner ear receptor stereocilium organization and biogenesis; hair follicle development; sensory cilium biogenesis; regulation of actin cytoskeleton organization and biogenesis; neural tube closure; establishment of body hair orientation; somatic stem cell division; establishment of planar polarity; heart looping
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Pathways associated with Vangl2 recombinant protein
Diseases associated with Vangl2 recombinant protein
Organs/Tissues associated with Vangl2 recombinant protein
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