P28907
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CD38
NCBI Official Synonym Full Names
CD38 molecule
NCBI Official Synonym Symbols
NCBI Protein Information
ADP-ribosyl cyclase 1; cADPr hydrolase 1; CD38 antigen (p45); OTTHUMP00000158633; OTTHUMP00000217743; NAD(+) nucleosidase; cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Protein Name
ADP-ribosyl cyclase 1
UniProt Synonym Protein Names
Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10
UniProt Entry Name
CD38_HUMAN
NCBI Summary for CD38
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq]
UniProt Comments for CD38
Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Catalytic activity: NAD+ + H2O = ADP-ribose + nicotinamide.
Enzyme regulation: ATP inhibits the hydrolyzing activity.
Subcellular location: Membrane; Single-pass type II membrane protein.
Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. Ref.2
Developmental stage: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
Sequence similarities: Belongs to the ADP-ribosyl cyclase family.
Product References and Citations for anti-CD38 antibody
1. Harada, N., L. Santos-Argumedo, R. Chang, J. C. Grimaldi, F. E. Lund, C. I. Brannan, N. G. Copeland, N. A. Jenkins, A. W. Heath, and R. M. Parkhouse. 1993. J. Immunol. 151:3111. 2. Santos-Argumedo, L., C. Teixeira, G. Preece, P. A. Kirkham, and R. M. E. Parkhouse. 1993. J. Immunol. 151:3119. 3. Howard, M., J. C. Grimaldi, J. F. Bazan, F. E. Lund, L. Santos-Argumedo, R. M. E. Parkhouse, T. F. Walseth, and H. C. Lee. 1993. Science 262:1056. 4. Lund, F., N. Solvason, J. C. Grimaldi, R. M. Parkhouse, and M. Howard. 1995. Immunol. Today 16:469. 5. Kirkham, P. A., L. Santos-Argumedo, M. M. Harnett, and R. M. Parkhouse. 1994. Immunology 83:513. 6. Bean, A. G. D., D. I. Godfrey, W. G. Ferlin, L. Santos-Argumedo, R. M. E. Parkhouse, M. C. Howard, and A. Zlotnik. 1996. Int. Immunol. 7:213. 7. Oliver, A. and J. Kearney. 1996. Personal Communication. 8. Kumagai, M., E. Coustan-Smith, D. J. Murray, O. Silvennoinen, K. G. Murti, W. E. Evans, F. Malavasi, and D. Campana. 1995. J. Exp. Med. 181:1101.
Research Articles on CD38
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-CD38 antibody
Pathways associated with anti-CD38 antibody
Diseases associated with anti-CD38 antibody
Disease Name |
Pubmed Publications |
Neoplasms Antibodies |
>1515 publications with CD38 and Neoplasms |
Lymphoma Antibodies |
>405 publications with CD38 and Lymphoma |
Vascular Diseases Antibodies |
>333 publications with CD38 and Vascular Diseases |
Lymphoma, B-Cell Antibodies |
>244 publications with CD38 and Lymphoma, B-Cell |
Leukemia, Myeloid, Acute Antibodies |
>241 publications with CD38 and Leukemia, Myeloid, Acute |
Inflammation Antibodies |
>142 publications with CD38 and Inflammation |
Lymphoma, T-Cell Antibodies |
>93 publications with CD38 and Lymphoma, T-Cell |
Anemia Antibodies |
>80 publications with CD38 and Anemia |
Bone Marrow Neoplasms Antibodies |
>64 publications with CD38 and Bone Marrow Neoplasms |
Cell Transformation, Neoplastic Antibodies |
>62 publications with CD38 and Cell Transformation, Neoplastic |
Organs/Tissues associated with anti-CD38 antibody
|