BC017489
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,852 Da
NCBI Official Full Name
Homo sapiens tryptophanyl-tRNA synthetase, mRNA
NCBI Official Synonym Full Names
tryptophanyl-tRNA synthetase
NCBI Protein Information
tryptophan--tRNA ligase, cytoplasmic
UniProt Protein Name
Tryptophan--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Interferon-induced protein 53; IFP53
UniProt Synonym Gene Names
UniProt Entry Name
SYWC_HUMAN
NCBI Summary for WARS
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for WARS
WARS: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Belongs to the class-I aminoacyl-tRNA synthetase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Translation; Amino Acid Metabolism - tryptophan; EC 6.1.1.2
Chromosomal Location of Human Ortholog: 14q32.31
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding; tryptophan-tRNA ligase activity
Biological Process: negative regulation of cell proliferation; regulation of angiogenesis; translation; tRNA aminoacylation for protein translation
Research Articles on WARS
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Pathways associated with WARS cdna clone
Diseases associated with WARS cdna clone
Organs/Tissues associated with WARS cdna clone
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