NP_034908.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,495 Da
NCBI Official Full Name
membrane cofactor protein
NCBI Official Synonym Full Names
CD46 antigen, complement regulatory protein
NCBI Official Synonym Symbols
NCBI Protein Information
membrane cofactor protein
UniProt Protein Name
Membrane cofactor protein
UniProt Synonym Protein Names
CD_antigen: CD46
UniProt Synonym Gene Names
UniProt Entry Name
MCP_MOUSE
UniProt Comments for CD46
CD46: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations. 16 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Cell surface; Membrane protein, integral
Cellular Component: Golgi apparatus; inner acrosomal membrane; cell surface; focal adhesion; membrane; basolateral plasma membrane; cytoplasm; extracellular region; acrosome; integral to membrane; cytoplasmic vesicle
Molecular Function: enzyme inhibitor activity; complement binding; cadherin binding; endopeptidase activity
Biological Process: positive regulation of memory T cell differentiation; positive regulation of regulatory T cell differentiation; regulation of Notch signaling pathway; negative regulation of complement activation; single fertilization; T cell mediated immunity; negative regulation of catalytic activity; interleukin-10 production; positive regulation of T cell proliferation; proteolysis; positive regulation of interleukin-10 production
Research Articles on CD46
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Products associated with CD46 sirna
Pathways associated with CD46 sirna
Diseases associated with CD46 sirna
Organs/Tissues associated with CD46 sirna
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