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anti-14-3-3 beta/zeta antibody :: 14-3-3 beta/zeta Antibody

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Catalog # MBS854588
Unit / Price
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  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

14-3-3 beta/zeta, Antibody

Full Product Name

14-3-3 beta/zeta (Phospho-Ser184/186) Antibody

Product Synonym Names
14-3-3 protein zeta/delta; 1433Z; 143Z; Factor activating exoenzyme S; FAS; KCIP-1; Mitochondrial import stimulation factor S1 subunit; Protein kinase C inhibitor protein-1; YWHAZ
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P63104
Species Reactivity
Human, Mouse, Rat
14-3-3 beta/zeta (Phospho-Ser184/186) antibody detects endogenous levels of 14-3-3 zeta/beta only when phosphorylated at serine 184 or serine 186.
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
The antiserum was produced against synthesized phosphopeptide derived from human 14-3-3 zeta/beta around the phosphorylation site of serine 184 or serine 186 (L-N-SP-P-E).
All Sites
Human: Ser184/186
Mouse: Ser184/186
Rat: Ser184/186
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-14-3-3 beta/zeta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-14-3-3 beta/zeta antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-14-3-3 beta/zeta antibody
WB: 1:500~1:1000
ELISA: 1:5000

Western Blot (WB) of anti-14-3-3 beta/zeta antibody
Western blot analysis of extracts from RAW264.7 cells, treated with UV (15mins), using 14-3-3 beta/zeta (Phospho-Ser184/186) antibody. 14-3-3 beta/zeta (Phospho-Ser184/186) antibody reacts with epitope-specific phosphopeptide and corresponding non-phosphopeptide. The absorbance readings at 450 nM are shown in the ELISA figure.
anti-14-3-3 beta/zeta antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for 14-3-3 beta/zeta. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,333 Da
NCBI Official Full Name
14-3-3 protein zeta/delta
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
NCBI Official Symbol
YWHAZ  [Similar Products]
NCBI Official Synonym Symbols
HEL4; YWHAD; KCIP-1; HEL-S-3; HEL-S-93; 14-3-3-zeta
  [Similar Products]
NCBI Protein Information
14-3-3 protein zeta/delta
UniProt Protein Name
14-3-3 protein zeta/delta
UniProt Synonym Protein Names
Protein kinase C inhibitor protein 1; KCIP-1
UniProt Gene Name
YWHAZ  [Similar Products]
UniProt Synonym Gene Names
KCIP-1  [Similar Products]
NCBI Summary for 14-3-3 beta/zeta
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for 14-3-3 beta/zeta
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Product References and Citations for anti-14-3-3 beta/zeta antibody
Zupan L.A., J. Biol. Chem. 267:8707-8710(1992). Seluja G.A., Biochim. Biophys. Acta 1395:281-287(1998). The MGC Project Team; Genome Res. 14:2121-2127(2004).

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