NP_000854.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,568 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 1B
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
NCBI Official Synonym Symbols
S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT1DB [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT-1D-beta; serotonin receptor 1B; serotonin 1D beta receptor
UniProt Protein Name
5-hydroxytryptamine receptor 1B
UniProt Synonym Protein Names
S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B
UniProt Synonym Gene Names
UniProt Entry Name
5HT1B_HUMAN
NCBI Summary for 5-HT-1B
The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009]
UniProt Comments for 5-HT-1B
5-HT(1B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q13
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: serotonin binding; serotonin receptor activity; drug binding
Biological Process: vasoconstriction; drinking behavior; negative regulation of synaptic transmission, glutamatergic; response to mineralocorticoid stimulus; bone remodeling; response to cocaine; regulation of dopamine secretion; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of serotonin secretion; synaptic transmission; negative regulation of cAMP biosynthetic process; response to ethanol; G-protein coupled receptor internalization; serotonin receptor, adenylate cyclase inhibiting pathway; protein kinase C activation; negative regulation of synaptic transmission, GABAergic; regulation of behavior
Research Articles on 5-HT-1B
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Products associated with anti-5-HT-1B antibody
Pathways associated with anti-5-HT-1B antibody
Diseases associated with anti-5-HT-1B antibody
Organs/Tissues associated with anti-5-HT-1B antibody
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