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anti-5-HT-2A antibody :: anti-Human 5-HT-2A Antibody

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Catalog # MBS859965
Unit / Price
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  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

5-HT-2A, Antibody

Full Product Name

5-HT-2A Antibody

Product Synonym Names
5-hydroxytryptamine receptor 2A; 5-HT-2A; Serotonin receptor 2A; 5-HT-2; HTR2A
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
182135
3D Structure
ModBase 3D Structure for P28223
Species Reactivity
Human
Specificity
5-HT-2A antibody detects endogenous levels of total 5-HT-2A protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human 5-HT-2A.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-5-HT-2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-5-HT-2A antibody
Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-5-HT-2A antibody
IHC: 1:50-1:100
IF: 1:100-1:500
ELISA: 1:5000

Testing Data of anti-5-HT-2A antibody
Peptide-+
anti-5-HT-2A antibody Testing Data image
Immunohistochemistry (IHC) of anti-5-HT-2A antibody
Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-2A antibody. Immunofluorescence analysis of A549 cells, using 5-HT-2A antibody.
anti-5-HT-2A antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for 5-HT-2A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,940 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2A isoform 1
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 2A
NCBI Official Symbol
HTR2A  [Similar Products]
NCBI Official Synonym Symbols
HTR2; 5-HT2A
  [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2A
UniProt Protein Name
5-hydroxytryptamine receptor 2A
UniProt Synonym Protein Names
Serotonin receptor 2A
UniProt Gene Name
HTR2A  [Similar Products]
UniProt Synonym Gene Names
HTR2; 5-HT-2; 5-HT-2A  [Similar Products]
NCBI Summary for 5-HT-2A
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for 5-HT-2A
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Product References and Citations for anti-5-HT-2A antibody
Saltzman A.G., Biochem. Biophys. Res. Commun. 181:1469-1478(1991). Chen K., Brain Res. Mol. Brain Res. 14:20-26(1992). Cook E.H. Jr., J. Neurochem. 63:465-469(1994).

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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