• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-5-HT-2B antibody :: anti-Human 5-HT-2B Antibody

Scan QR to view Datasheet
Catalog # MBS854234
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

5-HT-2B, Antibody

Full Product Name

5-HT-2B Antibody

Product Synonym Names
5-hydroxytryptamine receptor 2B; 5-HT-2B; Serotonin receptor 2B; HTR2B
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
601122
3D Structure
ModBase 3D Structure for P41595
Species Reactivity
Human
Specificity
5-HT-2B antibody detects endogenous levels of total 5-HT-2B protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human 5-HT-2B.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-5-HT-2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-5-HT-2B antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-5-HT-2B antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:00~1:500
ELISA: 1:1000

Testing Data of anti-5-HT-2B antibody
Peptide-+
anti-5-HT-2B antibody Testing Data image
Immunohistochemistry (IHC) of anti-5-HT-2B antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue using 5-HT-2B antibody. Western blot analysis of extracts from HeLa cells, using 5-HT-2B antibody.
anti-5-HT-2B antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-5-HT-2B antibody
Peptide-+ Immunofluorescence analysis of HeLa cells, using 5-HT-2B antibody.
anti-5-HT-2B antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for 5-HT-2B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,298 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2B isoform 1
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 2B
NCBI Official Symbol
HTR2B  [Similar Products]
NCBI Official Synonym Symbols
5-HT2B; 5-HT-2B; 5-HT(2B)
  [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2B
UniProt Protein Name
5-hydroxytryptamine receptor 2B
UniProt Synonym Protein Names
Serotonin receptor 2B
UniProt Gene Name
HTR2B  [Similar Products]
UniProt Synonym Gene Names
5-HT-2B; 5-HT2B  [Similar Products]
NCBI Summary for 5-HT-2B
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
UniProt Comments for 5-HT-2B
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538). Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine ().
Product References and Citations for anti-5-HT-2B antibody
Schmuck K., FEBS Lett. 342:85-90(1994). Choi D.S., FEBS Lett. 352:393-399(1994). Kim S.J., Mol. Cell. Probes 14:47-52(2000).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000