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anti-5-HT-2C antibody :: 5-HT-2C Antibody

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Catalog # MBS8514234
Unit / Price
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  0.1 mg  /  $290 +1 FREE 8GB USB
Western Blot (WB)
Product Name

5-HT-2C, Antibody

Full Product Name

5-HT-2C Antibody

Product Synonym Names
5-hydroxytryptamine 2C receptor; 5H2C; 5HT-1C; 5HT1C; 5HT2C; HTR1C; HTR2C; Serotonin receptor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
312861
3D Structure
ModBase 3D Structure for P28335
Species Reactivity
Human, Mouse, Rat
Specificity
5-HT-2C Antibody detects endogenous levels of total 5-HT-2C
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-5-HT-2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-5-HT-2C antibody
Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-5-HT-2C antibody
IHC: 1:50~1:200
IF/ICC: 1:100-1:500

Western Blot (WB) of anti-5-HT-2C antibody
Human, Mouse, Rat
anti-5-HT-2C antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for 5-HT-2C. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55 KD
NCBI Official Full Name
5-hydroxytryptamine receptor 2C isoform a
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 2C
NCBI Official Symbol
HTR2C  [Similar Products]
NCBI Official Synonym Symbols
HTR1C; 5-HT1C; 5-HT2C; 5HTR2C; 5-HTR2C
  [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2C
UniProt Protein Name
5-hydroxytryptamine receptor 2C
UniProt Synonym Protein Names
5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C
UniProt Gene Name
HTR2C  [Similar Products]
UniProt Synonym Gene Names
HTR1C; 5-HT-2C; 5-HT2C; 5-HTR2C; 5-HT-1C; 5-HT1C  [Similar Products]
NCBI Summary for 5-HT-2C
This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
UniProt Comments for 5-HT-2C
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-5-HT-2C antibody
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