NP_005551.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,287 Da
NCBI Official Full Name
laminin subunit alpha-5
NCBI Official Synonym Full Names
laminin subunit alpha 5
NCBI Protein Information
laminin subunit alpha-5
UniProt Protein Name
Laminin subunit alpha-5
UniProt Synonym Protein Names
Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha
UniProt Synonym Gene Names
UniProt Entry Name
LAMA5_HUMAN
NCBI Summary for LAMA5
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
UniProt Comments for LAMA5
LAMA5: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Extracellular matrix; Secreted
Chromosomal Location of Human Ortholog: 20q13.2-q13.3
Cellular Component: basal lamina; basement membrane; extracellular matrix; extracellular region; extracellular space; laminin-10 complex; laminin-5 complex; nucleus
Molecular Function: integrin binding; structural molecule activity
Biological Process: angiogenesis; cell differentiation; cell migration; cell proliferation; cell recognition; cilium biogenesis; cytoskeleton organization and biogenesis; embryonic development; endothelial cell differentiation; extracellular matrix organization and biogenesis; focal adhesion formation; hair follicle development; integrin-mediated signaling pathway; lung development; morphogenesis of a polarized epithelium; morphogenesis of embryonic epithelium; muscle development; neural crest cell migration; odontogenesis of dentine-containing teeth; regulation of cell adhesion; regulation of cell migration; regulation of cell proliferation; regulation of embryonic development; ureteric bud branching
Research Articles on LAMA5
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Pathways associated with LAMA5 blocking peptide
Diseases associated with LAMA5 blocking peptide
Organs/Tissues associated with LAMA5 blocking peptide
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