NP_006163.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,708 Da
NCBI Official Full Name
natriuretic peptides A preproprotein
NCBI Official Synonym Full Names
natriuretic peptide A
NCBI Official Synonym Symbols
ANF; ANP; PND; ATFB6; ATRST2; CDD-ANF [Similar Products]
NCBI Protein Information
natriuretic peptides A; atriopeptin; cardionatrin; prepronatriodilatin; natriuretic peptide precursor A
UniProt Protein Name
Natriuretic peptides A
UniProt Synonym Protein Names
CDD-ANF; PrepronatriodilatinCleaved into the following 2 chains:Cardiodilatin-related peptide; CDP; Atrial natriuretic factor; ANFAlternative name(s):Atrial natriuretic peptide; ANP
UniProt Synonym Gene Names
UniProt Entry Name
ANF_HUMAN
NCBI Summary for NPPA
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]
UniProt Comments for NPPA
Function: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.1 PublicationManual assertion based on experiment in:Ref.15
Research Articles on NPPA
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Products associated with NPPA elisa kit
Pathways associated with NPPA elisa kit
Diseases associated with NPPA elisa kit
Organs/Tissues associated with NPPA elisa kit
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