NP_001129491.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,743 Da
NCBI Official Full Name
IgG receptor FcRn large subunit p51
NCBI Official Synonym Full Names
Fc fragment of IgG receptor and transporter
NCBI Protein Information
IgG receptor FcRn large subunit p51
UniProt Protein Name
IgG receptor FcRn large subunit p51
UniProt Synonym Protein Names
IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor
UniProt Synonym Gene Names
UniProt Entry Name
FCGRN_HUMAN
NCBI Summary for FCGRT
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
UniProt Comments for FCGRT
FCGRT: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. Belongs to the immunoglobulin superfamily.
Protein type: Receptor, misc.; Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: antigen binding; beta-2-microglobulin binding; IgG binding; IgG receptor activity; peptide antigen binding
Biological Process: antigen processing and presentation; IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor; immune response
Research Articles on FCGRT
Precautions
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Products associated with FCGRT cell lysate
Diseases associated with FCGRT cell lysate
Organs/Tissues associated with FCGRT cell lysate
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