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A2M native protein :: alpha 2 Macroglobulin Native Protein

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Catalog # MBS537631
Unit / Price
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  1 mg  /  $370 +1 FREE 8GB USB
A2M native protein
Product Name

alpha 2 Macroglobulin (A2M), Native Protein

Full Product Name

alpha 2 Macroglobulin protein

Product Synonym Names
alpha Macroglobulin 2 protein; alpha Macroglobulin 2; CPAMD5 protein; alpha 2M protein; alpha 2 Macroglobulin; S863 7 protein; alpha Macroglobulin-2; alpha Macroglobulin-2 protein; FWP007 protein; alpha 2 M protein; A2M protein; DKFZp779B086 protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
103950
3D Structure
ModBase 3D Structure for P01023
Host
Human
Purity/Purification
> 96% pure
Form/Format
Lyophilized from 20 mM TRIS, with 150mM NaCl, and 0.1M sucrose.
Source Note
Human plasma
Protein Type
Native
Biological Significance
Alpha-2 macroglobulin is a tetrameric glycoprotein MW 725 kDa. Synthesized in the liver, it is a serine proteases inhibitor. It inhibits coagulation by inactivating thrombin and kallikrein, it inhibits fibrinolysis by inactivating plasmin and it is also involved in insulin transport. It is the principal defensin binding protein. It is raised in cirrhosis, pregnancy and diabetes.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of A2M native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
A2M native protein
Purified native Human alpha 2 Macroglobulin protein
Applications Tested/Suitable for A2M native protein
User optimized
NCBI/Uniprot data below describe general gene information for A2M. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
alpha-2-macroglobulin
NCBI Official Synonym Full Names
alpha-2-macroglobulin
NCBI Official Symbol
NCBI Official Synonym Symbols
A2MD; CPAMD5; FWP007; S863-7
  [Similar Products]
NCBI Protein Information
alpha-2-macroglobulin
UniProt Protein Name
Alpha-2-macroglobulin
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CPAMD5; Alpha-2-M  [Similar Products]
UniProt Entry Name
A2MG_HUMAN
NCBI Summary for A2M
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
UniProt Comments for A2M
A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: extracellular region; cytosol

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; regulation of small GTPase mediated signal transduction; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway

Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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