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A2M native protein :: alpha 2 Macroglobulin Native Protein

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Catalog # MBS537631
Unit / Price
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  1 mg  /  $370 +1 FREE 8GB USB
A2M native protein
Product Name

alpha 2 Macroglobulin (A2M), Native Protein

Full Product Name

alpha 2 Macroglobulin protein

Product Synonym Names
alpha Macroglobulin 2 protein; alpha Macroglobulin 2; CPAMD5 protein; alpha 2M protein; alpha 2 Macroglobulin; S863 7 protein; alpha Macroglobulin-2; alpha Macroglobulin-2 protein; FWP007 protein; alpha 2 M protein; A2M protein; DKFZp779B086 protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01023
> 96% pure
Lyophilized from 20 mM TRIS, with 150mM NaCl, and 0.1M sucrose.
Source Note
Human plasma
Protein Type
Biological Significance
Alpha-2 macroglobulin is a tetrameric glycoprotein MW 725 kDa. Synthesized in the liver, it is a serine proteases inhibitor. It inhibits coagulation by inactivating thrombin and kallikrein, it inhibits fibrinolysis by inactivating plasmin and it is also involved in insulin transport. It is the principal defensin binding protein. It is raised in cirrhosis, pregnancy and diabetes.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of A2M native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
A2M native protein
Purified native Human alpha 2 Macroglobulin protein
Applications Tested/Suitable for A2M native protein
User optimized
NCBI/Uniprot data below describe general gene information for A2M. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
NCBI Official Synonym Full Names
NCBI Official Symbol
NCBI Official Synonym Symbols
A2MD; CPAMD5; FWP007; S863-7
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NCBI Protein Information
UniProt Protein Name
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CPAMD5; Alpha-2-M  [Similar Products]
UniProt Entry Name
NCBI Summary for A2M
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
UniProt Comments for A2M
A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: extracellular region; cytosol

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; regulation of small GTPase mediated signal transduction; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway

Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency
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