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AADAC blocking peptide

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Catalog # MBS9226350
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
AADAC blocking peptide
Product Name

AADAC, Blocking Peptide

Also Known As

AADAC Antibody (C-term) Blocking Peptide

Product Synonym Names
Arylacetamide deacetylase; AADAC; DAC
Product Synonym Gene Name
Antibody/Peptide Pairs
AADAC peptide (MBS9226350) is used for blocking the activity of AADAC antibody (MBS9203843)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
399
OMIM
600338
3D Structure
ModBase 3D Structure for P22760
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human AADAC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein
Tissue Location
Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of AADAC blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
AADAC blocking peptide
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
NCBI/Uniprot data below describe general gene information for AADAC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,734 Da
NCBI Official Full Name
Arylacetamide deacetylase
NCBI Official Synonym Full Names
arylacetamide deacetylase
NCBI Official Symbol
AADAC  [Similar Products]
NCBI Official Synonym Symbols
DAC; CES5A1
  [Similar Products]
NCBI Protein Information
arylacetamide deacetylase
UniProt Protein Name
Arylacetamide deacetylase
Protein Family
UniProt Gene Name
AADAC  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
AAAD_HUMAN
NCBI Summary for AADAC
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
UniProt Comments for AADAC
AADAC: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. Belongs to the 'GDXG' lipolytic enzyme family.

Protein type: Deacetylase; Endoplasmic reticulum; Motility/polarity/chemotaxis; Lipase; Membrane protein, integral; EC 3.1.1.3

Chromosomal Location of Human Ortholog: 3q25.1

Cellular Component: endoplasmic reticulum membrane

Molecular Function: catalytic activity; deacetylase activity; lipase activity; serine hydrolase activity; triacylglycerol lipase activity

Biological Process: xenobiotic metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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