BC032309
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,734 Da
NCBI Official Full Name
Homo sapiens arylacetamide deacetylase (esterase), mRNA
NCBI Official Synonym Full Names
arylacetamide deacetylase
NCBI Official Synonym Symbols
NCBI Protein Information
arylacetamide deacetylase
UniProt Protein Name
Arylacetamide deacetylase
UniProt Synonym Gene Names
UniProt Entry Name
AAAD_HUMAN
NCBI Summary for AADAC
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
UniProt Comments for AADAC
AADAC: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. Belongs to the 'GDXG' lipolytic enzyme family.
Protein type: Endoplasmic reticulum; Deacetylase; EC 3.1.1.3; Motility/polarity/chemotaxis; Membrane protein, integral; Lipase
Chromosomal Location of Human Ortholog: 3q25.1
Cellular Component: endoplasmic reticulum membrane
Molecular Function: catalytic activity; deacetylase activity; lipase activity; serine hydrolase activity; triacylglycerol lipase activity
Biological Process: xenobiotic metabolic process
Research Articles on AADAC
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Diseases associated with AADAC cdna clone
Organs/Tissues associated with AADAC cdna clone
|