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AAL-993 biochemical

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Catalog # MBS842171
Unit / Price
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  2 mg  /  $145 +1 FREE 8GB USB
  10 mg  /  $385 +1 FREE 8GB USB
Structure
Product Name

AAL-993, Biochemical

Full Product Name

AAL-993

Product Synonym Names
2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
>=98% by TLC
Form/Format
Appearance: Light yellow solid
CAS Number
269390-77-4
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
6398883
Solubility/Reconstitution Instructions
DMSO (>25 mg/ml) or EtOH (~15 mg/ml)
SMILES
C1=CC=C(C(=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NCC3=CC=NC=C3
InChi
InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
InChi Key
BLAFVGLBBOPRLP-UHFFFAOYSA-N
Handling
Protect from air and light
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Other Notes
Small volumes of AAL-993 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
AAL-993 biochemical
Background: AAL-993 is a potent, selective and cell-permeable inhibitor of VEGFR-1 (IC?? = 130 nM), VEGFR-2 (IC?? = 23 nM) and VEGFR-3 (IC?? = 18nM). At higher concentrations it inhibits PDGFR (640 nM), c-Kit (236 nM) and CSF-1R (380 nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein. AAL-993 inhibits VEGF-induced angiogenesis (mouse model).

Structure of AAL-993 biochemical
AAL-993 biochemical Structure image
Molecular Weight
371.36
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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