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AANAT cdna clone

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Catalog # MBS1268531
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $205 +1 FREE 8GB USB
AANAT cdna clone
Product Name


Full Product Name


Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
atgtccacgc agagcaccca ccccctgaaa cctgaggccc cacgtctgcc acctgggatc cccgagtccc cgagctgtca gcggcgccac acactccctg ccagtgagtt tcgctgcctc accccggagg acgctgtcag cgcctttgag atcgagcgtg aagccttcat ctccgtcttg ggcgtctgcc ccctgtacct ggatgagatc cggcacttcc tgaccctatg tccagagctg tccctgggct ggttcgagga gggctgcctt gtggccttca tcatcggctc gctctgggac aaggagagac tcatgcagga gtcactgacg ctgcacaggt ctgggggcca catagcccac ctgcatgtgc tggccgtgca ccgcgccttc cggcagcagg gcaggggccc catcctgctg tggcgctacc tgcaccacct gggcagccag ccggccgtgc gccgggccgc gctcatgtgc gaggacgcgc tggtaccctt ctatgagagg ttcagcttcc acgccgtggg cccctgcgcc atcaccgtgg gctccctcac cttcatggag ctccactgct ccctgcgggg ccaccccttc ctgcgcagga acagcggctg ctga
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ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of AANAT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AANAT. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,432 Da
NCBI Official Full Name
Homo sapiens arylalkylamine N-acetyltransferase, mRNA
NCBI Official Synonym Full Names
aralkylamine N-acetyltransferase
NCBI Official Symbol
AANAT  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
serotonin N-acetyltransferase
UniProt Protein Name
Serotonin N-acetyltransferase
UniProt Synonym Protein Names
Aralkylamine N-acetyltransferase; AA-NAT
UniProt Gene Name
AANAT  [Similar Products]
UniProt Synonym Gene Names
SNAT; Serotonin acetylase; AA-NAT  [Similar Products]
UniProt Entry Name
NCBI Summary for AANAT
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for AANAT
AA-NAT var1: Catalyzes the N-acetylation of serotonin into N- acetylserotonin. Controls the night/day rhythm of melatonin production in the pineal gland. Has a relative affinity for hydroxylated versus non-hydroxylated arylalkylamines. Belongs to the acetyltransferase family. AANAT subfamily. Monomer. Interacts with YWHAZ; the interaction requires phosphorylation on Thr-31, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-205 site, the other YWHAZ monomer with similar effect.

Protein type: Acetyltransferase; Amino Acid Metabolism - tryptophan; EC

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: cytosol; perinuclear region of cytoplasm

Molecular Function: aralkylamine N-acetyltransferase activity; protein binding

Biological Process: circadian rhythm; indolalkylamine biosynthetic process; melatonin biosynthetic process; N-terminal protein amino acid acetylation; response to light stimulus

Disease: Delayed Sleep Phase Syndrome, Susceptibility To
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