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AARS recombinant protein :: Alanine--tRNA ligase, cytoplasmic (AARS) Recombinant Protein

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Catalog # MBS957515
Unit / Price
  1 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,835 +2 FREE 8GB USB
AARS recombinant protein
Product Name

Alanine--tRNA ligase, cytoplasmic (AARS), Recombinant Protein

Full Product Name

Recombinant Human Alanine--tRNA ligase, cytoplasmic (AARS), partial

Product Gene Name

AARS recombinant protein

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Sequence Positions
1-968
Sequence
MDSTLTASEI RQRFIDFFKR NEHTYVHSSA TIPLDDPTLL FANAGMNQFK PIFLNTIDPS HPMAKLSRAA NTQKCIRAGG KHNDLDDVGK DVYHHTFFEM LGSWSFGDYF KELACKMALE LLTQEFGIPI ERLYVTYFGG DEAAGLEADL ECKQIWQNLG LDDTKILPGN MKDNFWEMGD TGPCGPCSEI HYDRIGGRDA AHLVNQDDPN VLEIWNLVFI QYNREADGIL KPLPKKSIDT GMGLERLVSV LQNKMSNYDT DLFVPYFEAI QKGTGARPYT GKVGAEDADG IDMAYRVLAD HARTITVALA DGGRPDNTGR GYVLRRILRR AVRYAHEKLN ASRGFFATLV DVVVQSLGDA FPELKKDPDM VKDIINEEEV QFLKTLSRGR RILDRKIQSL GDSKTIPGDT AWLLYDTYGF PVDLTGLIAE EKGLVVDMDG FEEERKLAQL KSQGKGAGGE DLIMLDIYAI EELRARGLEV TDDSPKYNYH LDSSGSYVFE NTVATVMALR REKMFVEEVS TGQECGVVLD KTCFYAEQGG QIYDEGYLVK VDDSSEDKTE FTVKNAQVRG GYVLHIGTIY GDLKVGDQVW LFIDEPRRRP IMSNHTATHI LNFALRSVLG EADQKGSLVA PDRLRFDFTA KGAMSTQQIK KAEEIANEMI EAAKAVYTQD CPLAAAKAIQ GLRAVFDETY PDPVRVVSIG VPVSELLDDP SGPAGSLTSV EFCGGTHLRN SSHAGAFVIV TEEAIAKGIR RIVAVTGAEA QKALRKAESL KKCLSVMEAK VKAQTAPNKD VQREIADLGE ALATAVIPQW QKDELRETLK SLKKVMDDLD RASKADVQKR VLEKTKQFID SNPNQPLVIL EMESGASAKA LNEALKLFKM HSPQTSAMLF TVDNEAGKIT CLCQVPQNAA NRGLKASEWV QQVSGLMDGK GGGKDVSAQA TGKNVGCLQE ALQLATSFAQ LRLGDVKN
OMIM
601065
3D Structure
ModBase 3D Structure for P49588
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of AARS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
AARS recombinant protein
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
NCBI/Uniprot data below describe general gene information for AARS. It may not necessarily be applicable to this product.
NCBI GI #
109148542
NCBI GeneID
16
NCBI Accession #
NP_001596.2 [Other Products]
NCBI GenBank Nucleotide #
NM_001605.2 [Other Products]
UniProt Primary Accession #
P49588 [Other Products]
UniProt Secondary Accession #
Q53GV7; Q96FA0; A6NF14; B4DR45[Other Products]
UniProt Related Accession #
P49588[Other Products]
Molecular Weight
109,317 Da
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NCBI Official Full Name
alanine--tRNA ligase, cytoplasmic
NCBI Official Synonym Full Names
alanyl-tRNA synthetase
NCBI Official Symbol
AARS  [Similar Products]
NCBI Official Synonym Symbols
CMT2N; EIEE29
  [Similar Products]
NCBI Protein Information
alanine--tRNA ligase, cytoplasmic
UniProt Protein Name
Alanine--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Alanyl-tRNA synthetase
UniProt Gene Name
AARS  [Similar Products]
UniProt Synonym Gene Names
AlaRS  [Similar Products]
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NCBI Summary for AARS
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]
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UniProt Comments for AARS
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:28493438).
Research Articles on AARS
1. Number of missense mutations in AARS expand the clinical spectrum and provide pheno-genotypic correlations in AARS-related neuropathies.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated withAARS recombinant protein
 Reference Product  PubMed Publications
 GARS recombinant protein  >4 publications with AARS and GARS
 YARS recombinant protein  >3 publications with AARS and YARS
 KARS recombinant protein  >3 publications with AARS and KARS
 SARS recombinant protein  >2 publications with AARS and SARS
 MARS recombinant protein  >2 publications with AARS and MARS
 NARS recombinant protein  >1 publications with AARS and NARS
Pathways associated with AARS recombinant protein
 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram
Diseases associated with AARS recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >30 publications with AARS and Nervous System Diseases
 Hypertension Antibodies  >13 publications with AARS and Hypertension
 Inflammation Antibodies  >11 publications with AARS and Inflammation
 Brain Diseases Antibodies  >7 publications with AARS and Brain Diseases
 Heart Diseases Antibodies  >7 publications with AARS and Heart Diseases
 Kidney Diseases Antibodies  >7 publications with AARS and Kidney Diseases
 Liver Diseases Antibodies  >4 publications with AARS and Liver Diseases
 Cardiomyopathies Antibodies  >2 publications with AARS and Cardiomyopathies
 Myocardial Infarction Antibodies  >2 publications with AARS and Myocardial Infarction
 Nerve Degeneration Antibodies  >2 publications with AARS and Nerve Degeneration
Organs/Tissues associated with AARS recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >65 publications with AARS and Blood
 Vascular Antibodies  >39 publications with AARS and Vascular
 Nerve Antibodies  >28 publications with AARS and Nerve
 Mouth Antibodies  >26 publications with AARS and Mouth
 Muscle Antibodies  >21 publications with AARS and Muscle
 Heart Antibodies  >18 publications with AARS and Heart
 Kidney Antibodies  >12 publications with AARS and Kidney
 Brain Antibodies  >12 publications with AARS and Brain
 Bone Antibodies  >11 publications with AARS and Bone
 Skin Antibodies  >9 publications with AARS and Skin
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