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AARS2 blocking peptide

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Catalog # MBS9226998
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
AARS2 blocking peptide
Product Name

AARS2, Blocking Peptide

Also Known As

AARS2 Antibody (Center) Blocking Peptide

Product Synonym Names
Alanine--tRNA ligase; mitochondrial ; 6117 ; Alanyl-tRNA synthetase ; AlaRS ; AARS2
Antibody/Peptide Pairs
AARS2 peptide (MBS9226998) is used for blocking the activity of AARS2 antibody (MBS9207929)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
985
OMIM
612035
3D Structure
ModBase 3D Structure for Q5JTZ9
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of human AARS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Mitochondrion
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of AARS2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
AARS2 blocking peptide
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
NCBI/Uniprot data below describe general gene information for AARS2. It may not necessarily be applicable to this product.
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
107,340 Da
NCBI Official Synonym Full Names
alanyl-tRNA synthetase 2, mitochondrial
NCBI Official Symbol
AARS2  [Similar Products]
NCBI Official Synonym Symbols
AARSL; LKENP; COXPD8; MTALARS; MT-ALARS
  [Similar Products]
NCBI Protein Information
alanine--tRNA ligase, mitochondrial
UniProt Protein Name
Alanine--tRNA ligase, mitochondrial
UniProt Synonym Protein Names
Alanyl-tRNA synthetase
UniProt Gene Name
AARS2  [Similar Products]
UniProt Synonym Gene Names
AlaRS  [Similar Products]
UniProt Entry Name
SYAM_HUMAN
NCBI Summary for AARS2
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. [provided by RefSeq, Dec 2011]
UniProt Comments for AARS2
AARSL: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Defects in AARS2 are the cause of combined oxidative phosphorylation deficiency type 8 (COXPD8). A mitochondrial disease characterized by a lethal infantile hypertrophic cardiomyopathy, generalized muscle dysfunction and some neurologic involvement. The liver is not affected. Belongs to the class-II aminoacyl-tRNA synthetase family.

Protein type: Translation; EC 6.1.1.7; Ligase

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: cytosol; mitochondrion

Molecular Function: alanine-tRNA ligase activity; amino acid binding; tRNA binding

Biological Process: mitochondrial respiratory chain complex assembly; tRNA modification

Disease: Combined Oxidative Phosphorylation Deficiency 8; Leukoencephalopathy, Progressive, With Ovarian Failure
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with AARS2 blocking peptide
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