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AATF blocking peptide

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Catalog # MBS152971
Unit / Price
  0.05 mg  /  $140 +1 FREE 8GB USB
AATF blocking peptide
Product Name

AATF, Blocking Peptide

Popular Item
Also Known As

AATF Peptide

Product Synonym Names
DED; BFR2; CHE1; CHE-1; DED; HSPC277; Protein AATF; Apoptosis-antagonizing transcription factor; apoptosis antagonizing transcription factor
Antibody/Peptide Pairs
AATF peptide (MBS152971) is used for blocking the activity of AATF antibody (MBS150631)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
3D Structure
ModBase 3D Structure for Q9NY61
200 ug/mL (lot specific)
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
12 amino acids near the carboxy terminus of human AATF.
Preparation and Storage
Store AATF peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of AATF blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for AATF blocking peptide
Blocking (BL)
Application Notes for AATF blocking peptide
AATF peptide is used for blocking the activity of AATF antibody.
NCBI/Uniprot data below describe general gene information for AATF. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,133 Da
NCBI Official Full Name
protein AATF
NCBI Official Synonym Full Names
apoptosis antagonizing transcription factor
NCBI Official Symbol
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
protein AATF; rb-binding protein Che-1; apoptosis-antagonizing transcription factor
UniProt Protein Name
Protein AATF
UniProt Synonym Protein Names
Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CHE1; DED  [Similar Products]
UniProt Entry Name
NCBI Summary for AATF
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
UniProt Comments for AATF
AATF: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Belongs to the AATF family.

Protein type: Nucleolus; RNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: Golgi apparatus; centrosome; focal adhesion; cytoplasm; nucleolus; nucleus

Molecular Function: leucine zipper domain binding; protein binding; tau protein binding; transcription factor activity

Biological Process: nerve growth factor receptor signaling pathway; positive regulation of apoptosis; negative regulation of amyloid precursor protein biosynthetic process; regulation of mitotic cell cycle; ribosome biogenesis and assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of superoxide release; cell adhesion; response to DNA damage stimulus; embryonic cleavage; negative regulation of apoptosis
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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