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AATF cdna clone

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Catalog # MBS1275193
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $285 +1 FREE 8GB USB
AATF cdna clone
Product Name

AATF, cDNA Clone

Popular Item
Full Product Name

AATF cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggggc cgcagcccct ggcgctgcaa ctggaacagt tgttgaaccc gcgaccaagc gaggcggacc ctgaagcgga ccccgaggaa gccactgctg ccagggtgat tgacaggttt gatgaagggg aagatgggga aggtgatttc ctagtagtgg gtagcattag aaaactggca tcagcctccc tcttggacac ggacaaaagg tattgcggca aaaccacctc tagaaaagca tggaatgaag accattggga gcagactctg ccaggatcgt ctgatgagga aatatctgat gaggaagggt ctggagatga agattcagag ggactgggtc tggaggaata tgatgaggac gacctgggtg ctgctgagga acaggagtgt ggtgatcaca gggagagcaa gaagagcaga agccactctg caaaaacacc gggcttcagt gtccagagta tcagtgactt tgagaaattt accaagggaa tggatgacct tgggagcagt gaggaggagg aagacgaaga gagtggcatg gaagaagggg atgacgcgga agactcccaa ggcgagagtg aggaagacag ggctggagat agaaacagtg aggatgatgg tgtggtgatg accttctcta gtgtcaaagt ttctgaggaa gtggagaaag gaagagccgt gaagaaccag atagcactgt gggaccagct cttggaagga aggatcaaac tacaaaaagc tctgttgacc accaaccagc ttcctcaacc agatgttttc ccattgttca aggacaaagg tggcccagaa ttttccagtg ccctgaaaaa tagtcacaag gcacttaaag cattgttgag gtcattggta ggtcttcagg aagagttgct tttccagtac ccagacacta gatatctagt agatgggaca aagcccaatg cgggaagtga ggagatttct agtgaagatg atgagctggt agaagagaag aagcagcaac gaagaagggt ccctgcaaag aggaagctgg agatggagga ctatcccagc ttcatggcaa agcgctttgc cgactttaca gtctacagga accgcacact tcagaaatgg cacgataaga ccaaactggc ttctggaaaa ctggggaagg gttttggtgc ctttgaacgc tcaatcttga ctcagatcga ccatattctg atggacaaag agagattact tcgaaggaca cagaccaagc gctctgtcta tcgagttctt ggcaaacctg agccagcagc tcagcctgtc ccagagagtt tgccagggga accggagatc cttcctcaag cccctgctaa tgctcatctg aaggacttgg atgaagaaat ctttgatgat gatgactttt accaccagct ccttcgagaa ctcatagaac ggaagaccag ctccttggat cccaacgatc aggtggccat gggaaggcag tggcttgcaa tccagaagtt acgaagcaaa atccacaaaa aagtagatag gaaagccagc aaaggcagga aacttcggtt tcatgtcctt agcaagctac tgagtttcat ggcacctatt gaccatacta caatgaatga tgatgccagg acagaactgt accgctctct ttttggccag ctccaccctc ccgacgaagg ccacggggat tga
OMIM
608463
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of AATF cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AATF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,133 Da
NCBI Official Full Name
Homo sapiens apoptosis antagonizing transcription factor, mRNA
NCBI Official Synonym Full Names
apoptosis antagonizing transcription factor
NCBI Official Symbol
NCBI Official Synonym Symbols
DED; BFR2; CHE1; CHE-1
  [Similar Products]
NCBI Protein Information
protein AATF
UniProt Protein Name
Protein AATF
UniProt Synonym Protein Names
Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CHE1; DED  [Similar Products]
UniProt Entry Name
AATF_HUMAN
NCBI Summary for AATF
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
UniProt Comments for AATF
AATF: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Belongs to the AATF family.

Protein type: Transcription factor; RNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: centrosome; cytoplasm; focal adhesion; nucleolus; nucleus

Molecular Function: leucine zipper domain binding; protein binding

Biological Process: negative regulation of apoptosis; negative regulation of superoxide release; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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