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ABCA1 cdna clone

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Catalog # MBS1267165
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Vector Map
Product Name

ABCA1, cDNA Clone

Also Known As

ABCA1 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
Please Inquire
Please Inquire
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of ABCA1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Vector Map of ABCA1 cdna clone
ABCA1 cdna clone Vector Map image
NCBI/Uniprot data below describe general gene information for ABCA1. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
254,302 Da
NCBI Official Full Name
Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 1, mRNA
NCBI Official Synonym Full Names
ATP binding cassette subfamily A member 1
NCBI Official Symbol
ABCA1  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family A member 1
UniProt Protein Name
ATP-binding cassette sub-family A member 1
UniProt Synonym Protein Names
ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein
Protein Family
UniProt Gene Name
ABCA1  [Similar Products]
UniProt Synonym Gene Names
ABC1; CERP; ABC-1; ATP-binding cassette 1  [Similar Products]
UniProt Entry Name
NCBI Summary for ABCA1
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCA1
ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mice. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies.

Protein type: Vesicle; Transporter; Transporter, ABC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: endocytic vesicle; endoplasmic reticulum membrane; integral to plasma membrane; lipid raft; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane

Molecular Function: anion transmembrane transporter activity; apolipoprotein A-I binding; apolipoprotein A-I receptor activity; apolipoprotein binding; ATP binding; ATPase activity, coupled to transmembrane movement of substances; ATPase binding; cholesterol binding; cholesterol transporter activity; phospholipid binding; phospholipid transporter activity; protein binding; receptor binding; small GTPase binding; syntaxin binding

Biological Process: cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; endosome transport; G-protein coupled receptor protein signaling pathway; interleukin-1 beta secretion; intracellular cholesterol transport; lipoprotein metabolic process; lysosome organization and biogenesis; phospholipid efflux; phospholipid homeostasis; platelet dense granule organization and biogenesis; positive regulation of cAMP biosynthetic process; regulation of Cdc42 protein signal transduction; response to low density lipoprotein stimulus; reverse cholesterol transport

Disease: Hypercholesterolemia, Familial; Hypoalphalipoproteinemia, Primary; Tangier Disease
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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