• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-ABCA1 antibody :: ABCA1 (clone: HJ1) Antibody

Scan QR to view Datasheet
Catalog # MBS555095
Unit / Price
Scan QR to view Datasheet
  0.1 mL  /  $380 +1 FREE 8GB USB
Product Name

ABCA1 (clone: HJ1), Antibody

Full Product Name

ABCA1 (clone: HJ1), Monoclonal Antibody, Mouse

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
205400
Species Reactivity
Human, Mouse, Rat
Form/Format
Protein G Purified - Liquid
Type Info
Mouse IgG
Immunogen
50 kDa N-terminal extracellular loop of ABCA1 (AA)
Other Notes
Small volumes of anti-ABCA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCA1 antibody
Western Blot (WB)

Testing Data of anti-ABCA1 antibody
anti-ABCA1 antibody Testing Data image
Testing Data of anti-ABCA1 antibody
anti-ABCA1 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for ABCA1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
254,302 Da
NCBI Official Full Name
ATP-binding cassette sub-family A member 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily A member 1
NCBI Official Symbol
ABCA1  [Similar Products]
NCBI Official Synonym Symbols
TGD; ABC1; CERP; ABC-1; HDLDT1
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family A member 1
UniProt Protein Name
ATP-binding cassette sub-family A member 1
UniProt Synonym Protein Names
ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein
Protein Family
UniProt Gene Name
ABCA1  [Similar Products]
UniProt Synonym Gene Names
ABC1; CERP; ABC-1; ATP-binding cassette 1  [Similar Products]
UniProt Entry Name
ABCA1_HUMAN
NCBI Summary for ABCA1
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCA1
ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mice. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies.

Protein type: Transporter, ABC family; Membrane protein, multi-pass; Transporter; Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: Golgi apparatus; endocytic vesicle; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane; phagocytic vesicle; lipid raft; external side of plasma membrane

Molecular Function: apolipoprotein A-I receptor activity; ATPase activity; cholesterol binding; apolipoprotein binding; ATPase binding; apolipoprotein A-I binding; small GTPase binding; protein binding; syntaxin binding; phospholipid transporter activity; cholesterol transporter activity; phospholipid binding; anion transmembrane transporter activity; ATP binding; receptor binding

Biological Process: response to drug; cholesterol metabolic process; regulation of Cdc42 protein signal transduction; intracellular cholesterol transport; cholesterol efflux; lipoprotein metabolic process; cellular lipid metabolic process; endosome transport; phospholipid translocation; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; reverse cholesterol transport; phospholipid efflux; platelet dense granule organization and biogenesis; lysosome organization and biogenesis; response to low density lipoprotein stimulus; positive regulation of cAMP biosynthetic process; protein amino acid lipidation; interleukin-1 beta secretion; phagocytosis, engulfment; response to nutrient; peptide secretion; phospholipid homeostasis

Disease: Hypoalphalipoproteinemia, Primary; Tangier Disease; Hypercholesterolemia, Familial
Product References and Citations for anti-ABCA1 antibody
Wahrle SE, Jiang H, Parsadanian M, Legleiter J, Han X, Fryer JD, Kowalewski T, and Holtzman DM (2004). ABCA1 is Required for Normal Central Nervous System ApoE Levels and for Lipidation of Astrocyte-secreted apoE. J Biol. Chem. 279(39):40987.

Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM and Holtzman DM (2005). Deletion of Abca1 Increases Abeta Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease. J. Biol. Chem. 280(52):43236.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000