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ABCA2 blocking peptide

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Catalog # MBS9229692
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
ABCA2 blocking peptide
Product Name

ABCA2, Blocking Peptide

Also Known As

ABCA2 Blocking Peptide (Center)

Product Synonym Names
ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; ABCA2; ABC2; KIAA1062
Product Synonym Gene Name
ABC2; KIAA1062[Similar Products]
Antibody/Peptide Pairs
ABCA2 peptide (MBS9229692) is used for blocking the activity of ABCA2 antibody (MBS9201906)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
2435
OMIM
600047
3D Structure
ModBase 3D Structure for Q9BZC7
Specificity
The synthetic peptide sequence is selected from aa 1339-1353 of HUMAN ABCA2
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note: Forms discrete, punctate intracellular vesicles
Tissue Location
Highly expressed in the brain, whereas lower levels of expression is observed in kidney and liver
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ABCA2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ABCA2 blocking peptide
Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.
NCBI/Uniprot data below describe general gene information for ABCA2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
269,988 Da
NCBI Official Full Name
ATP-binding cassette sub-family A member 2
NCBI Official Synonym Full Names
ATP binding cassette subfamily A member 2
NCBI Official Symbol
ABCA2  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
ATP-binding cassette sub-family A member 2
UniProt Protein Name
ATP-binding cassette sub-family A member 2
UniProt Synonym Protein Names
ATP-binding cassette transporter 2; ATP-binding cassette 2
Protein Family
UniProt Gene Name
ABCA2  [Similar Products]
UniProt Synonym Gene Names
ABC2; KIAA1062; ATP-binding cassette 2  [Similar Products]
UniProt Entry Name
ABCA2_HUMAN
NCBI Summary for ABCA2
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCA2
ABCA2: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. Belongs to the ABC transporter superfamily. ABCA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family; Transporter

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: cytoplasmic membrane-bound vesicle; endosome; integral to membrane; lysosome; membrane; microtubule organizing center

Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances

Biological Process: cholesterol efflux; cholesterol homeostasis; phospholipid efflux; regulation of intracellular cholesterol transport; regulation of transcription from RNA polymerase II promoter; response to drug; response to steroid hormone stimulus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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