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ABCA4 peptide

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Catalog # MBS425337
Unit / Price
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  0.1 mg  /  $190 +1 FREE 8GB USB
ABCA4 peptide
Product Name

ABCA4, Peptide

Popular Item
Full Product Name

ABCA4 Immunizing Peptide

Product Synonym Names
ABCA4; ATP-binding cassette, sub-family A (ABC1), member 4; ABC10; ABCR; ARMD2; CORD3; DKFZp781N1972; FFM; FLJ17534; RMP; RP19; STGD; STGD1; ATP binding cassette transporter; ATP-binding cassette, sub-family A member 4; ATP-binding transporter, retina-spe
Product Gene Name
Antibody/Peptide Pairs
ABCA4 peptide (MBS425337) is used for blocking the activity of ABCA4 antibody (MBS421926)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
EPECPGPQLN TGTQ
OMIM
153800
Species Reactivity
Human
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of ABCA4 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ABCA4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
255,944 Da
NCBI Official Full Name
retinal-specific ATP-binding cassette transporter
NCBI Official Synonym Full Names
ATP binding cassette subfamily A member 4
NCBI Official Symbol
ABCA4  [Similar Products]
NCBI Official Synonym Symbols
FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1
  [Similar Products]
NCBI Protein Information
retinal-specific ATP-binding cassette transporter
UniProt Protein Name
Retinal-specific ATP-binding cassette transporter
UniProt Synonym Protein Names
ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Stargardt disease protein
Protein Family
UniProt Gene Name
ABCA4  [Similar Products]
UniProt Synonym Gene Names
ABCR; RIM protein; RmP  [Similar Products]
UniProt Entry Name
ABCA4_HUMAN
NCBI Summary for ABCA4
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCA4
ABCA4: In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1). STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD1 inheritance is autosomal recessive. Defects in ABCA4 are the cause of fundus flavimaculatus (FFM). FFM is an autosomal recessive retinal disorder very similar to Stargardt disease. In contrast to Stargardt disease, FFM is characterized by later onset and slowly progressive course. Defects in ABCA4 may be a cause of age-related macular degeneration type 2 (ARMD2). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Defects in ABCA4 are the cause of cone-rod dystrophy type 3 (CORD3). CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Defects in ABCA4 are the cause of retinitis pigmentosa type 19 (RP19). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP19 is characterized by choroidal atrophy. Inheritance is autosomal recessive. Belongs to the ABC transporter superfamily. ABCA family.

Protein type: Membrane protein, integral; Transporter, ABC family; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: integral to plasma membrane; intracellular membrane-bound organelle; membrane

Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; eye pigment precursor transporter activity; phospholipid-translocating ATPase activity; transporter activity

Biological Process: lipid transport; phospholipid transfer to membrane; phospholipid translocation; photoreceptor cell maintenance; phototransduction, visible light; retinoid metabolic process; transmembrane transport; transport; visual perception

Disease: Cone-rod Dystrophy 3; Macular Degeneration, Age-related, 2; Retinitis Pigmentosa 19; Stargardt Disease 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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