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ABCB1 cdna clone

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Catalog # MBS1491638
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ABCB1 cdna clone
Product Name

ABCB1, cDNA Clone

Popular Item
Full Product Name

ABCB1 cDNA Clone

Product Synonym Names
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), mRNA
Product Gene Name
Product Synonym Gene Name
ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Please Inquire
3D Structure
ModBase 3D Structure for P08183
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of ABCB1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ABCB1 cdna clone
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
NCBI/Uniprot data below describe general gene information for ABCB1. It may not necessarily be applicable to this product.
NCBI GenBank Nucleotide #
UniProt Primary Accession #
Protein Family
UniProt Comments for ABCB1
ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8.

Protein type: Transporter; Cell adhesion; Transporter, ABC family; EC 3.6.3.44; Membrane protein, integral; Hydrolase; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q21.12

Cellular Component: cell surface; membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; ATPase activity, coupled to transmembrane movement of substances; transporter activity; xenobiotic-transporting ATPase activity; ATP binding

Biological Process: response to drug; transport; xenobiotic transport; multidrug transport; G2/M transition of mitotic cell cycle; transmembrane transport

Disease: Colchicine Resistance; Inflammatory Bowel Disease 13
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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