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ABCB11 blocking peptide

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Catalog # MBS9225892
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
ABCB11 blocking peptide
Product Name

ABCB11, Blocking Peptide

Also Known As

ABCB11 Antibody (C-term) Blocking Peptide

Product Synonym Names
Bile salt export pump; ATP-binding cassette sub-family B member 11; ABCB11; BSEP
Product Synonym Gene Name
Antibody/Peptide Pairs
ABCB11 peptide (MBS9225892) is used for blocking the activity of ABCB11 antibody (MBS9209871)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
1321
OMIM
601847
3D Structure
ModBase 3D Structure for O95342
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human ABCB11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Cellular Location
Membrane; Multi-pass membrane protein.
Tissue Location
Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ABCB11 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ABCB11 blocking peptide
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
NCBI/Uniprot data below describe general gene information for ABCB11. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
146,407 Da
NCBI Official Full Name
Bile salt export pump
NCBI Official Synonym Full Names
ATP binding cassette subfamily B member 11
NCBI Official Symbol
ABCB11  [Similar Products]
NCBI Official Synonym Symbols
BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2
  [Similar Products]
NCBI Protein Information
bile salt export pump
UniProt Protein Name
Bile salt export pump
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 11
Protein Family
UniProt Gene Name
ABCB11  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
ABCBB_HUMAN
NCBI Summary for ABCB11
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCB11
ABCB11: Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis type 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease. Defects in ABCB11 are the cause of benign recurrent intrahepatic cholestasis type 2 (BRIC2). BRIC is characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration and patients are asymptomatic between episodes, both clinically and biochemically. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Protein type: Transporter, ABC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Hydrolase

Chromosomal Location of Human Ortholog: 2q24

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: bile acid-exporting ATPase activity; canalicular bile acid transmembrane transporter activity; sodium-exporting ATPase activity, phosphorylative mechanism; transporter activity

Biological Process: bile acid and bile salt transport; bile acid biosynthetic process; canalicular bile acid transport; transport

Disease: Cholestasis, Benign Recurrent Intrahepatic, 2; Cholestasis, Progressive Familial Intrahepatic, 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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