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ABCB4 blocking peptide

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Catalog # MBS9225894
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
ABCB4 blocking peptide
Product Name

ABCB4, Blocking Peptide

Also Known As

ABCB4 Antibody (Center) Blocking Peptide

Product Synonym Names
Multidrug resistance protein 3; ATP-binding cassette sub-family B member 4; P-glycoprotein 3; ABCB4; MDR3; PGY3
Product Synonym Gene Name
MDR3; PGY3[Similar Products]
Antibody/Peptide Pairs
ABCB4 peptide (MBS9225894) is used for blocking the activity of ABCB4 antibody (MBS9214586)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
1286
OMIM
171060
3D Structure
ModBase 3D Structure for P21439
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of human ABCB4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Cellular Location
Cell membrane; Multi-pass membrane protein.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ABCB4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ABCB4 blocking peptide
Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.
NCBI/Uniprot data below describe general gene information for ABCB4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
135,259 Da
NCBI Official Full Name
Phosphatidylcholine translocator ABCB4
NCBI Official Synonym Full Names
ATP binding cassette subfamily B member 4
NCBI Official Symbol
ABCB4  [Similar Products]
NCBI Official Synonym Symbols
GBD1; ICP3; MDR2; MDR3; PGY3; ABC21; MDR2/3; PFIC-3
  [Similar Products]
NCBI Protein Information
phosphatidylcholine translocator ABCB4
UniProt Protein Name
Phosphatidylcholine translocator ABCB4
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 4
Protein Family
UniProt Gene Name
ABCB4  [Similar Products]
UniProt Entry Name
MDR3_HUMAN
NCBI Summary for ABCB4
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCB4
ABCB4: a transporter that mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human ABCB4 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Interacts with HAX1. Defects are the cause of gallstones, and progressive familial intrahepatic cholestasis 3, an autosomal recessive liver disorder that progresses to cirrhosis and liver failure before adulthood. Two alternatively spliced human isoforms have been described.

Protein type: Transporter, ABC family; Hydrolase; Membrane protein, multi-pass; Membrane protein, integral; Transporter; EC 3.6.3.44

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: apical plasma membrane; cytoplasm; integral to plasma membrane; membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; phosphatidylcholine transmembrane transporter activity; phospholipid transporter activity; protein binding

Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; bile acid secretion; lipid homeostasis; lipid metabolic process; phospholipid translocation; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; positive regulation of cholesterol transport; response to drug; transmembrane transport; transport

Disease: Cholestasis, Intrahepatic, Of Pregnancy 3; Cholestasis, Progressive Familial Intrahepatic, 3; Gallbladder Disease 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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