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ABCB4 sirna

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Catalog # MBS8208613
Unit / Price
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  15 nmol  /  $365 +1 FREE 8GB USB
  30 nmol  /  $515 +1 FREE 8GB USB
ABCB4 sirna
Product Name


Full Product Name

ABCB4 siRNA (Rat)

Product Synonym Names
MDR2; PGP3; PGY2; Multidrug resistance protein 3; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 2; P-glycoprotein 2; P-glycoprotein 3
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q08201
Species Reactivity
ABCB4 siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
> 97%
Lyophilized powder
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat ABCB4 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Other Notes
Small volumes of ABCB4 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ABCB4 sirna
siRNA to inhibit ABCB4 expression using RNA interference
Applications Tested/Suitable for ABCB4 sirna
RNA Interference (RNAi)
NCBI/Uniprot data below describe general gene information for ABCB4. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
140,655 Da
NCBI Official Full Name
multidrug resistance protein 3
NCBI Official Synonym Full Names
ATP-binding cassette, subfamily B (MDR/TAP), member 4
NCBI Official Symbol
Abcb4  [Similar Products]
NCBI Official Synonym Symbols
Mdr2; Pgy3
  [Similar Products]
NCBI Protein Information
multidrug resistance protein 3
UniProt Protein Name
Multidrug resistance protein 3
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 4; Multidrug resistance protein 2; P-glycoprotein 2; P-glycoprotein 3
Protein Family
UniProt Gene Name
Abcb4  [Similar Products]
UniProt Synonym Gene Names
Mdr2; Pgp3; Pgy2  [Similar Products]
UniProt Entry Name
NCBI Summary for ABCB4
energy-dependent efflux pump; may be involved in changes in bile formation in response to diabetes [RGD, Feb 2006]
UniProt Comments for ABCB4
ABCB4: a transporter that mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human ABCB4 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Interacts with HAX1. Defects are the cause of gallstones, and progressive familial intrahepatic cholestasis 3, an autosomal recessive liver disorder that progresses to cirrhosis and liver failure before adulthood. Two alternatively spliced human isoforms have been described.

Protein type: Transporter, ABC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Hydrolase; EC

Cellular Component: Golgi membrane; intercellular canaliculus; membrane; apical plasma membrane; integral to membrane

Molecular Function: protein binding; ATPase activity, coupled to transmembrane movement of substances; ATP binding; xenobiotic-transporting ATPase activity

Biological Process: response to drug; metabolic process; response to glucocorticoid stimulus; xenobiotic transport; multidrug transport; transmembrane transport
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with ABCB4 sirna
 Reference Product  PubMed Publications
 Ppara sirna  >1 publications with ABCB4 and Ppara
Organs/Tissues associated with ABCB4 sirna
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >170 publications with ABCB4 and Liver
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