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ABCB5 peptide

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Catalog # MBS658777
Unit / Price
  0.1 mg  /  $400 +1 FREE 8GB USB
ABCB5 peptide
Product Name

ABCB5, Peptide

Full Product Name

ABCB5 (ATP-binding cassette, sub-family B MDR/TAP, ABCB5alpha, ABCB5beta, EST422562, ATP-binding cassette, sub-family B, member 5N: P-glycoprotein ABCB5) (Control Peptide)

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 7; NC_000007.13 (20655245..20796637). Location: 7p21.1
OMIM
611785
3D Structure
ModBase 3D Structure for Q2M3G0
Purity/Purification
Highly Purified
Highly Purified
Form/Format
Supplied as a lyophilized powder in PBS.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of ABCB5 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ABCB5 peptide
C-QTQHRNTSKKAQ, from the internal region of the protein sequence according to NP_848654.3.

ABCB5 (ATP-binding cassette, subfamily B [DR/TAP] member 5) is a 90kD (predicted MW) member of the human P-glycoprotein family of molecules. It is expressed by CD133+ pluripotent pigment stem cells, where it serves as a marker for cells that show a high incidence of polyploidy. Human ABCB5 is 812aa in length. It is possibly a five transmembrane protein with a 247aa N-terminal extracellular domain (ECD) aa1-247 and a 283aa C-terminal cytoplasmic region aa530-812. The ECD contains one ABC transporter aa2-177, while the cytoplasmic region contains a second ABC transporter aa570-808. There are two potential splice forms. One shows a seven aa substitution for aa125-812, while another possesses an alternative start site 445aa upstream of the standard site. Over aa141-247, human ABCB5 shares 64aa identity with mouse ABCB5.
Applications Tested/Suitable for ABCB5 peptide
ELISA (EL/EIA)
Application Notes for ABCB5 peptide
Suitable for use in ELISA.
NCBI/Uniprot data below describe general gene information for ABCB5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,832 Da[Similar Products]
NCBI Official Full Name
ATP-binding cassette sub-family B member 5 isoform 1
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family B (MDR/TAP), member 5
NCBI Official Symbol
ABCB5  [Similar Products]
NCBI Official Synonym Symbols
ABCB5beta; EST422562; ABCB5alpha
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5; ATP-binding cassette protein
UniProt Protein Name
ATP-binding cassette sub-family B member 5
UniProt Synonym Protein Names
ABCB5 P-gp; P-glycoprotein ABCB5
Protein Family
UniProt Gene Name
ABCB5  [Similar Products]
UniProt Entry Name
ABCB5_HUMAN
NCBI Summary for ABCB5
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]
UniProt Comments for ABCB5
Function: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. Ref.1 Ref.4 Ref.10 Ref.11

Subcellular location: Cell membrane; Multi-pass membrane protein Ref.1.

Tissue specificity: Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues. Ref.1 Ref.2

Miscellaneous: Depletion of ABCB5 by RNAi increases the sensitivity to several drugs of a subset of melanoma cells.

Sequence similarities: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Contains 1 ABC transmembrane type-1 domain.Contains 2 ABC transporter domains.

Caution: Was named ABCB1 by some authors.

Sequence caution: The sequence AAN76500.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAQ03033.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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