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ABCC11 blocking peptide

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Catalog # MBS9225369
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
ABCC11 blocking peptide
Product Name

ABCC11, Blocking Peptide

Also Known As

ABCC11 Antibody (N-term) Blocking Peptide

Product Synonym Names
ATP-binding cassette sub-family C member 11; Multidrug resistance-associated protein 8; ABCC11; MRP8
Product Synonym Gene Name
Antibody/Peptide Pairs
ABCC11 peptide (MBS9225369) is used for blocking the activity of ABCC11 antibody (MBS9210064)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
1382
OMIM
117800
3D Structure
ModBase 3D Structure for Q96J66
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Membrane; Multi-pass membrane protein.
Tissue Location
Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ABCC11 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ABCC11 blocking peptide
Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.
NCBI/Uniprot data below describe general gene information for ABCC11. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
150,093 Da
NCBI Official Full Name
ATP-binding cassette sub-family C member 11
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 11
NCBI Official Symbol
ABCC11  [Similar Products]
NCBI Official Synonym Symbols
WW; EWWD; MRP8
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family C member 11
UniProt Protein Name
ATP-binding cassette sub-family C member 11
UniProt Synonym Protein Names
Multidrug resistance-associated protein 8
Protein Family
UniProt Gene Name
ABCC11  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
ABCCB_HUMAN
NCBI Summary for ABCC11
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC11
ABCC11: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, ABC family

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: anion transmembrane-transporting ATPase activity; organic anion transmembrane transporter activity; purine nucleotide transmembrane transporter activity

Biological Process: organic anion transport; purine nucleotide transport; transmembrane transport

Disease: Apocrine Gland Secretion, Variation In
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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