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anti-ABCC4 antibody :: Rabbit ABCC4 Antibody

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Catalog # MBS8503810
Unit / Price
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  0.1 mL  /  $310 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ABCC4, Antibody

Full Product Name

ABCC4 Antibody

Product Synonym Names
EST170205; MOAT-B; MOATB; MRP4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605250
3D Structure
ModBase 3D Structure for O15439
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human ABCC4
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-ABCC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCC4 antibody
ABCC4 is a member of the ATP-binding Cassette (ABC) transporter family. ABC proteins transport various molecules across cellular membranes by utilizing the energy generated from ATP hydrolysis. There are seven subfamilies of ABC proteins: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White (1). ABCC4 belongs to the MRP subfamily, which is involved in multi-drug resistance, hence it is also named MRP4. ABCC4 is widely expressed in cells and tissues including prostate, kidney proximal tubules, astrocytes and capillary endothelial cells of the brain, platelets, and many cancer cell lines (2-4). ABCC4 mediates efflux transport of a wide variety of endogenous and xenobiotic organic anionic compounds (5). The diversity of substrates determines the biological functions of ABCC4. It regulates cAMP levels in human leukemia cells, thereby controlling the proliferation and differentiation of leukemia cells (6). ABCC4 also enables COX deficient pancreatic cancer cells to obtain exogenous prostagladins (7). Researchers have shown that ABCC4 expression is elevated in drug resistant cancer cells, which makes it a potential target for cancer therapy (8, 9). ABCC4 localizes to both plasma membrane and intracellular membranous structures (10). Investigators have also implicated ABCC4 in the pathogenesis of Kawasaki desease, a genetic childhood disease characterized by vasculitis (11).
Applications Tested/Suitable for anti-ABCC4 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ABCC4 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-ABCC4 antibody
Western blot analysis of extracts of kindney cellline, using ABCC4 antibody.
anti-ABCC4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ABCC4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
97kDa
NCBI Official Full Name
multidrug resistance-associated protein 4 isoform 2
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 4
NCBI Official Symbol
ABCC4  [Similar Products]
NCBI Official Synonym Symbols
MRP4; MOATB; MOAT-B
  [Similar Products]
NCBI Protein Information
multidrug resistance-associated protein 4
UniProt Protein Name
Multidrug resistance-associated protein 4
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B
Protein Family
UniProt Gene Name
ABCC4  [Similar Products]
UniProt Synonym Gene Names
MRP4; MOAT-B  [Similar Products]
NCBI Summary for ABCC4
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
UniProt Comments for ABCC4
May be an organic anion pump relevant to cellular detoxification.
Product References and Citations for anti-ABCC4 antibody
1. Nakanishi, T. Cancer Genomics Proteomics 4, 241-54. 2. Kool, M. et al. (1997) Cancer Res 57, 3537-47. 3. Lee, K. et al. (1998) Cancer Res 58, 2741-7. 4. Nies, A.T. et al. (2004) Neuroscience 129, 349-60. 5. Giacomini, K.M. et al. (2010) Nat Rev Drug Discov 9, 215-36. 6. Copsel, S. et al. (2011) J Biol Chem 286, 6979-88. 7. Omura, N. et al. (2010) Mol Cancer Res 8, 821-32. 8. Bronger, H. et al. (2005) Cancer Res 65, 11419-28. 9. Hagmann, W. et al. (2009) Pancreatology 9, 136-44. 10. Rius, M. et al. (2008) J Pharmacol Exp Ther 324, 86-94. 11. Khor, C.C. et al. (2011) J Med Genet 48, 467-72.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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