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ABCC6 cdna clone

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Catalog # MBS1271672
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ABCC6 cdna clone
Product Name

ABCC6, cDNA Clone

Full Product Name

ABCC6 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
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Chromosome Location
Chromosome: 16; NC_000016.9 (16243422..16317328, complement). Location: 16p13.1
3D Structure
ModBase 3D Structure for O95255
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ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of ABCC6 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ABCC6. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
164,906 Da
NCBI Official Full Name
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 6, mRNA
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
NCBI Official Symbol
ABCC6  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
URG7 protein; multidrug resistance-associated protein 6; ATP-binding cassette sub-family C member 6; multi-specific organic anion transporter E; anthracycline resistance-associated protein
UniProt Protein Name
Multidrug resistance-associated protein 6
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 6; Anthracycline resistance-associated protein; Multi-specific organic anion transporter E
Protein Family
UniProt Gene Name
ABCC6  [Similar Products]
UniProt Synonym Gene Names
ARA; MRP6; MOAT-E  [Similar Products]
UniProt Entry Name
NCBI Summary for ABCC6
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC6
ABCC6: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE). PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE). Defects in ABCC6 are the cause of arterial calcification of infancy, generalized, type 2 (GACI2). GACI2 is a severe autosomal recessive disorder characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. The disorder is often fatal within the first 6 months of life because of myocardial ischemia resulting in refractory heart failure. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Hydrolase; Transporter, ABC family

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: endoplasmic reticulum membrane; basolateral plasma membrane; apical plasma membrane; integral to membrane; plasma membrane; nucleus; lateral plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; transporter activity; ATP binding

Biological Process: response to drug; visual perception; transport; metabolic process; transmembrane transport

Disease: Arterial Calcification, Generalized, Of Infancy, 2; Pseudoxanthoma Elasticum, Forme Fruste; Pseudoxanthoma Elasticum
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