• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ABCC6 cdna clone

Scan QR to view Datasheet
Catalog # MBS7046708
Unit / Price
Scan QR to view Datasheet
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $1,650 +2 FREE 8GB USB
ABCC6 cdna clone
Product Name

ABCC6, cDNA Clone

Full Product Name

ABCC6 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGGCCGCGC CTGCTGAGCC CTGCGCGGGG CAGGGGGTCT GGAACCAGAC AGAGCCTGAA CCTGCCGCCA CCAGCCTGCT GAGCCTGTGC TTCCTGAGAA CAGCAGGGGT CTGGGTACCC CCCATGTACC TCTGGGTCCT TGGTCCCATC TACCTCCTCT TCATCCACCA CCATGGCCGG GGCTACCTCC GGATGTCCCC ACTCTTCAAA GCCAAGATGG TGCTTGGATT CGCCCTCATA GTCCTGTGTA CCTCCAGCGT GGCTGTCGCT CTTTGGAAAA TCCAACAGGG AACGCCTGAG GCCCCAGAAT TCCTCATTCA TCCTACTGTG TGGCTCACCA CGATGAGCTT CGCAGTGTTC CTGATTCACA CCGAGAGGAA AAAGGGAGTC CAGTCATCTG GAGTGCTGTT TGGTTACTGG CTTCTCTGCT TTGTCTTGCC AGCTACCAAC GCTGCCCAGC AGGCCTCCGG AGCGGGCTTC CAGAGCGACC CTGTCCGCCA CCTGTCCACC TACCTATGCC TGTCTCTGGT GGTGGCACAG TTTGTGCTGT CCTGCCTGGC GGATCAACCC CCCTTCTTCC CTGAAGACCC CCAGCAGTCT AACCCCTGTC CAGAGACTGG GGCAGCCTTC CCCTCCAAAG CCACGTTCTG GTGGGTTTCT GGCCTGGTCT GGAGGGGATA CAGGAGGCCA CTGAGACCAA AAGACCTCTG GTCGCTTGGG AGAGAAAACT CCTCAGAAGA ACTTGTTTCC CGGCTTGAAA AGGAGTGGAT GAGGAACCGC AGTGCAGCCC GGAGGCACAA CAAGGCAATA GCATTTAAAA GGAAAGGCGG CAGTGGCATG AAGGCTCCAG AGACCGAGCC CTTCCTACGG CAAGAAGGGA GCCAGTGGCG CCCACTGCTG AAGGCCATCT GGCAGGTGTT CCATTCTACC TTCCTCCTGG GGACCCTCAG CCTCATCATC AGTGATGTCT TCAGGTTCAC TGTCCCCAAG CTGCTCAGCC TTTTCCTGGA GTTTATTGGT GATCCCAAGC CTCCAGCCTG GAAGGGCTAC CTCCTCGCCG TGCTGATGTT CCTCTCAGCC TGCCTGCAAA CGCTGTTTGA GCAGCAGAAC ATGTACAGGC TCAAGGTGCT GCAGATGAGG TTGCGGTCGG CCATCACTGG CCTGGTGTAC AGAAAGGTCC TGGCTCTGTC CAGCGGCTCC AGAAAGGCCA GTGCGGTGGG TGATGTGGTC AATCTGGTGT CCGTGGACGT GCAGCGGCTG ACCGAGAGCG TCCTCTACCT CAACGGGCTG TGGCTGCCTC TCGTCTGGAT CGTGGTCTGC TTCGTCTATC TCTGGCAGCT CCTGGGGCCC TCCGCCCTCA CTGCCATCGC TGTCTTCCTG AGCCTCCTCC CTCTGAATTT CTTCATCTCC AAGAAAAGGA ACCACCATCA GGAGGAGCAA ATGAGGCAGA AGGACTCACG GGCACGGCTC ACCAGCTCTA TCCTCAGGAA CTCGAAGACC ATCAAGTTCC ATGGCTGGGA GGGAGCCTTT CTGGACAGAG TCCTGGGCAT CCGAGGCCAG GAGCTGGGCG CCTTGCGGAC CTCCGGCCTC CTCTTCTCTG TGTCGCTGGT GTCCTTCCAA GTGTCTACAT TTCTGGTCGC ACTGGTGGTG TTTGCTGTCC ACACTCTGGT GGCCGAGAAT GCTATGAATG CAGAGAAAGC CTTTGTGACT CTCACAGTTC TCAACATCCT CAACAAGGCC CAGGCTTTCC TGCCCTTCTC CATCCACTCC CTCGTCCAGG CCCGGGTGTC CTTTGACCGT CTGGTCACCT TCCTCTGCCT GGAAGAAGTT GACCCTGGTG CCGTAGACTC AAGTTCCTCT GGAAGCGCTG CCGGGAAGGA TTGCATCACG ATACAAAGTG CCACCTTCGC CTGGTCCCAG GAAAGCCCTC CCTGCCTCCA CAGAATAAAC CTCACGGTGC CCCAGGGCTG TCTGCTGGCT GTTGTCGGTC CAGTGGGGGC AGGGAAGTCC TCCCTGCTGT CCGCCCTCCT TGGGGAGCTG TCAAAGGTGG AGGGGTTCGT GAGCATCGAG GGTGCTGTGG CCTACGTGCC CCAGGAGGCC TGGGTGCAGA ACACCTCTGT GGTAGAGAAT GTGTGCTTCG GGCAGGAGCT GGACCCACCC TGGCTGGAGA GAGTACTAGA AGCCTGTGCC CTGCAGCCAG ATGTGGACAG CTTCCCTGAG GGAATCCACA CTTCAATTGG GGAGCAGGGC ATGAATCTCT CCGGAGGCCA GAAGCAGCGG CTGAGCCTGG CCCGGGCTGT ATACAGAAAG GCAGCTGTGT ACCTGCTGGA TGACCCCCTG GCGGCCCTGG ATGCCCACGT TGGCCAGCAT GTCTTCAACC AGGTCATTGG GCCTGGTGGG CTACTCCAGG GAACAACACG GATTCTCGTG ACGCACGCAC TCCACATCCT GCCCCAGGCT GATTGGATCA TAGTGCTGGC AAATGGGGCC ATCGCAGAGA TGGGTTCCTA CCAGGAGCTT CTGCAGAGGA AGGGGGCCCT CGTGTGTCTT CTGGATCAAG CCAGACAGCC AGGAGATAGA GGAGAAGGAG AAACAGAACC TGGGACCAGC ACCAAGGACC CCAGAGGCAC CTCTGCAGGC AGGAGGCCCG AGCTTAGACG CGAGAGGTCC ATCAAGTCAG TCCCTGAGAA GGACCGTACC ACTTCAGAAG CCCAGACAGA GGTTCCTCTG GATGACCCTG ACAGGGCAGG ATGGCCAGCA GGAAAGGACA GCATCCAATA CGGCAGGGTG AAGGCCACAG TGCACCTGGC CTACCTGCGT GCCGTGGGCA CCCCCCTCTG CCTCTACGCA CTCTTCCTCT TCCTCTGCCA GCAAGTGGCC TCCTTCTGCC GGGGCTACTG GCTGAGCCTG TGGGCGGACG ACCCTGCAGT AGGTGGGCAG CAGACGCAGG CAGCCCTGCG TGGCGGGATC TTCGGGCTCC TCGGCTGTCT CCAAGCCATT GGGCTGTTTG CCTCCATGGC TGCGGTGCTC CTAGGTGGGG CCCGGGCATC CAGGTTGCTC TTCCAGAGGC TCCTGTGGGA TGTGGTGCGA TCTCCCATCA GCTTCTTTGA GCGGACACCC ATTGGTCACC TGCTAAACCG CTTCTCCAAG GAGACAGACA CGGTTGACGT GGACATTCCA GACAAACTCC GGTCCCTGCT GATGTACGCC TTTGGACTCC TGGAGGTCAG CCTGGTGGTG GCAGTGGCTA CCCCACTGGC CACTGTGGCC ATCCTGCCAC TGTTTCTCCT CTACGCTGGG TTTCAGAGCC TGTATGTGGT TAGCTCATGC CAGCTGAGAC GCTTGGAGTC AGCCAGCTAC TCGTCTGTCT GCTCCCACAT GGCTGAGACG TTCCAGGGCA GCACAGTGGT CCGGGCATTC CGAACCCAGG CCCCCTTTGT GGCTCAGAAC AATGCTCGCG TAGATGAAAG CCAGAGGATC AGTTTCCCGC GACTGGTGGC TGACAGGTGG CTTGCGGCCA ATGTGGAGCT CCTGGGGAAT GGCCTGGTGT TTGCAGCTGC CACGTGTGCT GTGCTGAGCA AAGCCCACCT CAGTGCTGGC CTCGTGGGCT TCTCTGTCTC TGCTGCCCTC CAGGTGACCC AGACACTGCA GTGGGTTGTT CGCAACTGGA CAGACCTAGA GAACAGCATC GTGTCAGTGG AGCGGATGCA GGACTATGCC TGGACGCCCA AGGAGGCTCC CTGGAGGCTG CCCACATGTG CAGCTCAGCC CCCCTGGCCT CAGGGCGGGC AGATCGAGTT CCGGGACTTT GGGCTAAGAT ACCGACCTGA GCTCCCGCTG GCTGTGCAGG GCGTGTCCTT CAAGATCCAC GCAGGAGAGA AGGTGGGCAT CGTTGGCAGG ACCGGGGCAG GGAAGTCCTC CCTGGCCAGT GGGCTGCTGC GGCTCCAGGA GGCAGCTGAG GGTGGGATCT GGATCGACGG GGTCCCCATT GCCCACGTGG GGCTGCACAC ACTGCGCTCC AGGATCAGCA TCATCCCCCA GGACCCCATC CTGTTCCCTG GCTCTCTGCG GATGAACCTC GACCTGCTGC AGGAGCACTC GGACGAGGCT ATCTGGGCAG CCCTGGAGAC GGTGCAGCTC AAAGCCTTGG TGGCCAGCCT GCCCGGCCAG CTGCAGTACA AGTGTGCTGA CCGAGGCGAG GACCTGAGCG TGGGCCAGAA ACAGCTCCTG TGTCTGGCAC GTGCCCTTCT CCGGAAGACC CAGATCCTCA TCCTGGACGA GGCTACTGCT GCCGTGGACC CTGGCACGGA GCTGCAGATG CAGGCCATGC TCGGGAGCTG GTTTGCACAG TGCACTGTGC TGCTCATTGC CCACCGCCTG CGCTCCGTGA TGGACTGTGC CCGGGTTCTG GTCATGGACA AGGGGCAGGT GGCAGAGAGC GGCAGCCCGG CCCAGCTGCT GGCCCAGAAG GGCCTGTTTT ACAGACTGGC CCAGGAGTCA GGCCTGGTCT GA
OMIM
264800
Vector
Please Inquire
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of ABCC6 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ABCC6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
95,877 Da
NCBI Official Full Name
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 6, mRNA
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 6
NCBI Official Symbol
ABCC6  [Similar Products]
NCBI Official Synonym Symbols
ARA; PXE; MLP1; MRP6; PXE1; URG7; ABC34; GACI2; MOATE; MOAT-E; EST349056
  [Similar Products]
NCBI Protein Information
URG7 protein; multidrug resistance-associated protein 6
UniProt Protein Name
Multidrug resistance-associated protein 6
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 6; Anthracycline resistance-associated protein; Multi-specific organic anion transporter E; MOAT-E
Protein Family
UniProt Gene Name
ABCC6  [Similar Products]
UniProt Synonym Gene Names
ARA; MRP6; MOAT-E  [Similar Products]
UniProt Entry Name
MRP6_HUMAN
NCBI Summary for ABCC6
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC6
ABCC6: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE). PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE). Defects in ABCC6 are the cause of arterial calcification of infancy, generalized, type 2 (GACI2). GACI2 is a severe autosomal recessive disorder characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. The disorder is often fatal within the first 6 months of life because of myocardial ischemia resulting in refractory heart failure. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Protein type: Transporter; Hydrolase; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: nucleus; plasma membrane

Molecular Function: anion transmembrane-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of substances; transporter activity

Biological Process: response to drug; transmembrane transport; transport

Disease: Arterial Calcification, Generalized, Of Infancy, 2; Pseudoxanthoma Elasticum; Pseudoxanthoma Elasticum, Forme Fruste
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000