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ABCD1 blocking peptide

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Catalog # MBS9217597
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
ABCD1 blocking peptide
Product Name

ABCD1, Blocking Peptide

Also Known As

ABCD1 Antibody (Center) Blocking Peptide

Product Synonym Names
ATP-binding cassette sub-family D member 1; Adrenoleukodystrophy protein; ALDP; ABCD1; ALD
Product Synonym Gene Name
Antibody/Peptide Pairs
ABCD1 peptide (MBS9217597) is used for blocking the activity of ABCD1 antibody (MBS9203294)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
745
OMIM
300100
3D Structure
ModBase 3D Structure for P33897
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Peroxisome membrane; Multi-pass membrane protein
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ABCD1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ABCD1 blocking peptide
Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
NCBI/Uniprot data below describe general gene information for ABCD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
82,937 Da
NCBI Official Full Name
ATP-binding cassette sub-family D member 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily D member 1
NCBI Official Symbol
ABCD1  [Similar Products]
NCBI Official Synonym Symbols
ALD; AMN; ALDP; ABC42
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family D member 1
UniProt Protein Name
ATP-binding cassette sub-family D member 1
UniProt Synonym Protein Names
Adrenoleukodystrophy protein; ALDP
Protein Family
UniProt Gene Name
ABCD1  [Similar Products]
UniProt Synonym Gene Names
ALD; ALDP  [Similar Products]
UniProt Entry Name
ABCD1_HUMAN
NCBI Summary for ABCD1
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCD1
ABCD1: Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. Defects in ABCD1 are the cause of adrenoleukodystrophy X- linked (X-ALD). X-ALD is a peroxisomal metabolic disorder characterized by progressive multifocal demyelination of the central nervous system and by peripheral adrenal insufficiency (Addison disease). It results in mental deterioration, corticospinal tract dysfunction, and cortical blindness. Different clinical manifestations exist like: cerebral childhood ALD (CALD), adult cerebral ALD (ACALD), adrenomyeloneuropathy (AMN) and 'Addison disease only' (ADO) phenotype. The promoter region of ABCD1 is deleted in the chromosome Xq28 deletion syndrome which involves ABCD1 and the neighboring gene BCAP31. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

Protein type: Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ABC family; Hydrolase

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; cytosol; integral to peroxisomal membrane; membrane; perinuclear region of cytoplasm; peroxisomal membrane; peroxisome

Molecular Function: ATP binding; ATPase activity; enzyme binding; identical protein binding; long-chain fatty acid transporter activity; peroxisomal fatty acyl CoA transporter activity; protein binding; protein homodimerization activity

Biological Process: fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA oxidase; linoleic acid metabolic process; long-chain fatty acid catabolic process; peroxisomal long-chain fatty acid import; peroxisome organization and biogenesis; transmembrane transport; very-long-chain fatty acid catabolic process

Disease: Adrenoleukodystrophy
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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