NP_033018.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ATP-binding cassette sub-family D member 4
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family D (ALD), member 4
NCBI Protein Information
ATP-binding cassette sub-family D member 4; PMP69; PXMP1-L; PMP70-related protein; peroxisomal membrane protein 69; peroxisomal membrane protein, 70 kDa-related
UniProt Protein Name
ATP-binding cassette sub-family D member 4
UniProt Synonym Protein Names
PMP70-related protein; P70R; Peroxisomal membrane protein 1-like; PXMP1-L; Peroxisomal membrane protein 69
UniProt Synonym Gene Names
UniProt Entry Name
ABCD4_MOUSE
NCBI Summary for Abcd4
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that the human protein may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for Abcd4
ABCD4: is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. [provided by RefSeq, Jul 2008]
Protein type: Transporter, ABC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane; peroxisome
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATPase activity; nucleotide binding; ATP binding
Biological Process: transport; cobalamin metabolic process; transmembrane transport
Research Articles on Abcd4
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Pathways associated with Abcd4 recombinant protein
Diseases associated with Abcd4 recombinant protein
Organs/Tissues associated with Abcd4 recombinant protein
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