NP_004818.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,453 Da
NCBI Official Full Name
ATP-binding cassette sub-family G member 2 isoform 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily G member 2 (Junior blood group)
NCBI Official Synonym Symbols
MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; MXR-1; CDw338; UAQTL1; EST157481 [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family G member 2
UniProt Protein Name
ATP-binding cassette sub-family G member 2
UniProt Synonym Protein Names
Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter; CD_antigen: CD338
UniProt Synonym Gene Names
NCBI Summary for ABCG2
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Comments for ABCG2
ABCG2: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123. Monomer or homodimer; disulfide-linked. Up-regulated in brain tumors. Highly expressed in placenta. Low expression in small intestine, liver and colon. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Transporter, iron
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component: apical plasma membrane; integral component of membrane; mitochondrial membrane; nucleus; plasma membrane; receptor complex
Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; cholesterol transporter activity; heme transporter activity; protein binding; protein homodimerization activity; transporter activity; xenobiotic transmembrane transporting ATPase activity
Biological Process: cellular iron ion homeostasis; cholesterol efflux; drug transmembrane transport; heme transport; response to drug; transport; urate metabolic process; xenobiotic transport
Disease: Blood Group, Junior System; Uric Acid Concentration, Serum, Quantitative Trait Locus 1
Research Articles on ABCG2
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Pathways associated with ABCG2 elisa kit
Diseases associated with ABCG2 elisa kit
Organs/Tissues associated with ABCG2 elisa kit
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